Murdock is a surname. A relatively modern iteration of the Irish or Scottish name Murdoch. Notable people with the surname include:
- Andrew Murdock (born 1962), American record producer
- Andrew G. Murdock (fl. 2000s), botanist whose official abbreviation is "Murdock", who described the fern genus Ptisana
- Bennet Murdock (1925–2022), American psychologist
- Colin Murdock (born 1975), Northern Irish former footballer
- Dorothy M. Murdock, better known by pen name Acharya S, author and proponent of the Christ myth theory
- David H. Murdock, American businessman
- Deroy Murdock, American syndicated columnist
- Eric Murdock, retired American professional basketball player
- George Peter Murdock, American anthropologist known for his empirical approach to ethnological studies
- George Murdock, American actor
- Ian Murdock, founder and former leader of the Debian Linux Distribution
- J. Edgar Murdock (1894–1977), American jurist who served as a chief judge of the United States Tax Court
- James Murdock (disambiguation), various people
- Joseph Murdock (disambiguation), various people
- Kirk Radomski (known to players as Murdock), former New York Mets employee
- Mackenzie Murdock (born 1989), American voice actor and writer
- Mike Murdock, American televangelist and pastor
- Murdock, Portuguese professional footballer
- Orrice Abram Murdock, Jr., United States Representative and Senator from Utah
- Roger E. Murdock, LAPD Chief
- Sharon Murdock, Canadian politician
- Shirley Murdock, American R&B singer
- William Murdock, eighteenth century US politician
- William Murdoch, also spelled Murdock, early-nineteenth century Scottish engineer