Murtaza Khan may refer to:
- Ghulam Murtaza Khan, 19th-century painter from Delhi
- Ghulam Murtaza Khan Jatoi, Pakistani politician
- Murtaza Ahmed Khan, politician from Jammu and Kashmir
- Murtaza Ali Khan, 20th-century Nawab of Rampur
- Murtaza Ali Khan (film critic), Indian film critic and journalist
- Shaikh Farid Bukhari, 17th-century Mughal noble bearing the title Murtaza Khan
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