Muscarinic acetylcholine receptor M2

CHRM2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3UON, 4MQS, 4MQT
Identifiers
Aliases	CHRM2, HM2, cholinergic receptor muscarinic 2
External IDs	OMIM: 118493; MGI: 88397; HomoloGene: 20190; GeneCards: CHRM2; OMA:CHRM2 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	137,020,255 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	36,505,349 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; right auricle; ; apex of heart; ; muscle layer of sigmoid colon; ; left ventricle; ; gallbladder; ; testicle; ; epithelium of colon; ; right lung; ; smooth muscle tissue;
	Top expressed in
	interventricular septum; ; left ventricle; ; upper lip; ; olfactory bulb; ; brain stem; ; stomach; ; lower lip; ; duodenum; ; pons; ; medulla oblongata;
	More reference expression data
	n/a
Gene ontology
Molecular function	G protein-coupled receptor activity; signal transducer activity; G protein-coupled acetylcholine receptor activity; arrestin family protein binding; G protein-coupled serotonin receptor activity; neurotransmitter receptor activity;
Cellular component	axon terminus; postsynaptic membrane; membrane; plasma membrane; synapse; integral component of plasma membrane; cell junction; soma; dendrite; symmetric synapse; asymmetric synapse; clathrin-coated vesicle membrane; integral component of membrane; glutamatergic synapse; cholinergic synapse; integral component of postsynaptic membrane; integral component of presynaptic membrane;
Biological process	G protein-coupled acetylcholine receptor signaling pathway; G protein-coupled receptor signaling pathway; regulation of smooth muscle contraction; adenylate cyclase-modulating G protein-coupled receptor signaling pathway; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; response to virus; synaptic transmission, cholinergic; nervous system development; adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway; phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway; signal transduction; membrane organization; regulation of heart contraction; regulation of synaptic vesicle exocytosis; chemical synaptic transmission; G protein-coupled serotonin receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	1129
	243764
	ENSG00000181072
	ENSMUSG00000045613
	P08172
	Q9ERZ4
NM_000739; NM_001006626; NM_001006627; NM_001006628; NM_001006629;
	NM_001006630; NM_001006631; NM_001006632; NM_001006633; NM_001378972; NM_001378973
	NM_203491
NP_000730; NP_001006627; NP_001006628; NP_001006629; NP_001006630;
	NP_001006631; NP_001006632; NP_001006633; NP_001365901; NP_001365902
	NP_987076
	Wikidata
View/Edit Human	View/Edit Mouse

The muscarinic acetylcholine receptor M₂, also known as the cholinergic receptor, muscarinic 2, is a muscarinic acetylcholine receptor that in humans is encoded by the CHRM2 gene.^[5] Multiple alternatively spliced transcript variants have been described for this gene.^[5] It is G_i-coupled, reducing intracellular levels of cAMP.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000181072 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000045613 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: CHRM2 cholinergic receptor, muscarinic 2".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000181072 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000045613 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: CHRM2 cholinergic receptor, muscarinic 2".

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