Myelinogenesis

Myelination of a peripheral nerve by a Schwann cell

Myelinogenesis is the formation and development of myelin sheaths in the nervous system, typically initiated in late prenatal neurodevelopment and continuing throughout postnatal development.[1] Myelinogenesis continues throughout the lifespan to support learning and memory via neural circuit plasticity as well as remyelination following injury.[2] Successful myelination of axons increases action potential speed by enabling saltatory conduction, which is essential for timely signal conduction between spatially separate brain regions, as well as provides metabolic support to neurons.[3]

  1. ^ Eilam, R.; Bar-Lev, D.D.; Levin-Zaidman, S.; Tsoory, M.; LoPresti, P.; Sela, M.; Arnon, R.; Aharoni, R. (2014). "Oligodendrogenesis and myelinogenesis during postnatal development effect of glatiramer acetate". Glia. 62 (4): 649–665. doi:10.1002/glia.22632. PMID 24481644. S2CID 25559134.
  2. ^ Williamson JM, Lyons DA (2018). "Myelin Dynamics Throughout Life: An Ever-Changing Landscape?". Front Cell Neurosci. 12: 424. doi:10.3389/fncel.2018.00424. PMC 6252314. PMID 30510502.
  3. ^ Philips T, Rothstein JD (2017). "Oligodendroglia: metabolic supporters of neurons". J Clin Invest. 127 (9): 3271–3280. doi:10.1172/JCI90610. PMC 5669561. PMID 28862639.