Myogenic regulatory factors

Myogenic regulatory factors (MRF) are basic helix-loop-helix (bHLH) transcription factors that regulate myogenesis: MyoD, Myf5, myogenin, and MRF4.[1]

These proteins contain a conserved basic DNA binding domain that binds the E box DNA motif.[2] They dimerize with other HLH containing proteins through an HLH-HLH interaction.[3]

  1. ^ Perry R, Rudnick M (2000). "Molecular mechanisms regulating myogenic determination and differentiation". Front Biosci. 5: D750–67. doi:10.2741/Perry. PMID 10966875.
  2. ^ Weintraub H, Davis R, Tapscott S, Thayer M, Krause M, Benezra R, Blackwell T, Turner D, Rupp R, Hollenberg S (1991). "The myoD gene family: nodal point during specification of the muscle cell lineage". Science. 251 (4995): 761–6. Bibcode:1991Sci...251..761W. doi:10.1126/science.1846704. PMID 1846704.
  3. ^ Barndt R, Zhuang Y (1999). "Controlling lymphopoiesis with a combinatorial E-protein code". Cold Spring Harb Symp Quant Biol. 64: 45–50. doi:10.1101/sqb.1999.64.45. PMID 11232321.