Myosin light-chain kinase

Myosin Light-Chain kinase, smooth muscle
Identifiers
SymbolMYLK
NCBI gene4638
HGNC7590
OMIM600922
RefSeqNM_053025
UniProtQ15746
Other data
EC number2.7.11.18
LocusChr. 3 qcen-q21
Search for
StructuresSwiss-model
DomainsInterPro
myosin light-chain kinase 2, skeletal muscle
Crystal structure of the S. dubia centrin / human skeletal muscle myosin light-chain complex.[1]
Identifiers
SymbolMYLK2
NCBI gene85366
HGNC16243
OMIM606566
RefSeqNM_033118
UniProtQ9H1R3
Other data
LocusChr. 20 q13.31
Search for
StructuresSwiss-model
DomainsInterPro
myosin light-chain kinase 3, cardiac
Identifiers
SymbolMYLK3
NCBI gene91807
HGNC29826
OMIM612147
RefSeqNM_182493
UniProtQ32MK0
Other data
LocusChr. 16 q11.2
Search for
StructuresSwiss-model
DomainsInterPro
Human Myosin Light-Chain Kinase
The Crystal Structure of the Human Myosin Light Chain Kinase Loc340156.[2]
Identifiers
SymbolMYLK4
NCBI gene340156
HGNC27972
RefSeqNM_001012418
UniProtQ86YV6
Search for
StructuresSwiss-model
DomainsInterPro

Myosin light-chain kinase also known as MYLK or MLCK is a serine/threonine-specific protein kinase that phosphorylates a specific myosin light chain, namely, the regulatory light chain of myosin II.[3]

  1. ^ Radu, L.; Assairi, L.; Blouquit, Y.; Durand, D.; Miron, S.; Charbonnier, J.B.; Craescu, C.T. (2011). "RCSB Protein Data Bank - Structure Summary for 3KF9 - Crystal structure of the SdCen/skMLCK complex". Worldwide Protein Data Bank. doi:10.2210/pdb3kf9/pdb.
  2. ^ Muniz, J.R.C.; Mahajan, P.; Rellos, P.; Fedorov, O.; Shrestha, B.; Wang, J.; Elkins, J.M.; Daga, N.; Cocking, R.; Chaikuad, A.; Krojer, T.; Ugochukwu, E.; Yue, W.; von Delft, F.; Arrowsmith, C.H.; Edwards, A.M.; Weigelt, J.; Bountra, C.; Gileadi, O.; Knapp, S. (2010). "RCSB Protein Data Bank - Structure Summary for 2X4F - The Crystal Structure of the Human Myosin Light Chain Kinase Loc340156". Worldwide Protein Data Bank. doi:10.2210/pdb2x4f/pdb.
  3. ^ Gao Y, Ye LH, Kishi H, Okagaki T, Samizo K, Nakamura A, Kohama K (June 2001). "Myosin light chain kinase as a multifunctional regulatory protein of smooth muscle contraction". IUBMB Life. 51 (6): 337–44. doi:10.1080/152165401753366087. PMID 11758800. S2CID 46180993.