Myshkin (Мы́шкин) is a Russian-language surname, also transliterated Mishkin and Miskin, although the latter two words have other meanings, both in Russian and in other languages. "Myshkin" is the possessive case of the Russian word myshka, the diminutive of 'mouse'.
Notable people with this surname include:
- Anatoly Myshkin (b. 1954), Soviet and Russian basketball player
- Ippolit Myshkin (1848–1885), Russian revolutionary
- Tanya Myshkin (born 1961), Australian printmaker
- Vladimir Myshkin (b. 1955), Soviet and Russian ice hockey goaltender