N-Phenylacetyl-L-prolylglycine ethyl ester

N-Phenylacetyl-L-prolylglycine ethyl ester
Clinical data
Trade namesNoopept
Other namesomberacetam; GVS-111; DVD-111; SGS-111; benzylcarbonyl-Pro-Gly-OEt
Legal status
Legal status
  • AU: S4 (Prescription only)
  • US: Unapproved "New Drug" (as defined by 21 U.S. Code § 321(p)(1)). Use in dietary supplements, food, or medicine is unlawful; otherwise uncontrolled.
Identifiers
  • Ethyl 1-(phenylacetyl)-l-prolylglycinate
CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC17H22N2O4
Molar mass318.373 g·mol−1
3D model (JSmol)
  • c2ccccc2CC(=O)N1CCC[C@@H]1C(=O)NCC(=O)OCC
  • InChI=1S/C17H22N2O4/c1-2-23-16(21)12-18-17(22)14-9-6-10-19(14)15(20)11-13-7-4-3-5-8-13/h3-5,7-8,14H,2,6,9-12H2,1H3,(H,18,22)/t14-/m0/s1 ☒N
  • Key:PJNSMUBMSNAEEN-AWEZNQCLSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

N-Phenylacetyl-l-prolylglycine ethyl ester is promoted as a nootropic and is a prodrug of cyclic glycine-proline.[a][2] Other names include the brand name Noopept (Russian: Ноопепт), developmental code GVS-111, and proposed INN omberacetam.[2][3][4]

Its synthesis was first reported in 1996.[2] It is orally available. As of 2017, its metabolism and elimination half-life in humans were not well understood.[2]

It has been evaluated for neuroprotective effects in treating brain injuries and stroke.[5]

  1. ^ "Omberacetam". Inxight. National Center for Advancing Translational Sciences (NCATS). 4QBJ98683M.
  2. ^ a b c d "Noopept Information". Examine.com. Retrieved 6 April 2017.
  3. ^ "Proposed INN List 117". WHO Drug Information. 31 (2): 308. 2017.
  4. ^ "Omberacetam". AdisInsight. Springer Nature Switzerland AG. Retrieved 12 May 2018. Alternative Names: DVD-111; GVS 111; Noopept
  5. ^ Ostrovskaia RU, Gudasheva TA, Voronina TA, Seredenin SB (2002). "[The original novel nootropic and neuroprotective agent noopept]" [The original novel nootropic and neuroprotective agent noopept]. Eksperimental'naia i Klinicheskaia Farmakologiia [Experimental and Clinical Pharmacology] (in Russian). 65 (5): 66–72. PMID 12596521.


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