Type of enzyme
N-acyl phosphatidylethanolamine phospholipase D (NAPE-PLD ) is an enzyme that catalyzes the release of N-acylethanolamine (NAE) from N-acyl-phosphatidylethanolamine (NAPE). This is a major part of the process that converts ordinary lipids into chemical signals like anandamide and oleoylethanolamine . In humans, the NAPE-PLD protein is encoded by the NAPEPLD gene .[ 1] [ 2] [ 3] [ 4]
^ See "Entrez Gene" .
^ Okamoto Y, Morishita J, Tsuboi K, Tonai T, Ueda N (Feb 2004). "Molecular characterization of a phospholipase D generating anandamide and its congeners" . The Journal of Biological Chemistry . 279 (7): 5298–305. doi :10.1074/jbc.M306642200 PMID 14634025 . ^ Curtiss NP, Bonifas JM, Lauchle JO, Balkman JD, Kratz CP, Emerling BM, Green ED, Le Beau MM, Shannon KM (May 2005). "Isolation and analysis of candidate myeloid tumor suppressor genes from a commonly deleted segment of 7q22". Genomics . 85 (5): 600–7. doi :10.1016/j.ygeno.2005.01.013 . PMID 15820312 . ^ Egertová M, Simon GM, Cravatt BF, Elphick MR (Feb 2008). "Localization of N-acyl phosphatidylethanolamine phospholipase D (NAPE-PLD) expression in mouse brain: A new perspective on N-acylethanolamines as neural signaling molecules" . The Journal of Comparative Neurology . 506 (4): 604–15. doi :10.1002/cne.21568 PMID 18067139 . S2CID 7770463 .