N-ethylmaleimide sensitive fusion protein

NSF
Identifiers
Aliases	NSF, SKD2, N-ethylmaleimide sensitive factor, N-ethylmaleimide sensitive factor, vesicle fusing ATPase, SEC18, DEE96
External IDs	OMIM: 601633; MGI: 104560; HomoloGene: 4502; GeneCards: NSF; OMA:NSF - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	46,757,464 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	103,844,882 bp
RNA expression pattern
	Top expressed in
	superior frontal gyrus; ; prefrontal cortex; ; primary visual cortex; ; Brodmann area 9; ; right frontal lobe; ; cerebellar cortex; ; anterior cingulate cortex; ; cerebellar hemisphere; ; nucleus accumbens; ; hypothalamus;
	Top expressed in
	dentate gyrus of hippocampal formation granule cell; ; pontine nuclei; ; subiculum; ; medial dorsal nucleus; ; medial vestibular nucleus; ; dorsal tegmental nucleus; ; superior colliculus; ; medial geniculate nucleus; ; deep cerebellar nuclei; ; ventral tegmental area;
	More reference expression data
	n/a
Gene ontology
Molecular function	nucleotide binding; PDZ domain binding; syntaxin-1 binding; metal ion binding; protein binding; syntaxin binding; hydrolase activity; ATP binding; protein kinase binding; SNARE binding; protein-containing complex binding; ionotropic glutamate receptor binding; ATPase activity;
Cellular component	postsynaptic density; myelin sheath; plasma membrane; dendritic shaft; lysosomal membrane; extracellular exosome; Golgi membrane; cytoplasm; cytosol; Golgi stack;
Biological process	plasma membrane fusion; positive regulation of protein catabolic process; regulation of exocytosis; potassium ion transport; endoplasmic reticulum to Golgi vesicle-mediated transport; COPII vesicle coating; protein transport; intracellular protein transport; vesicle-mediated transport; positive regulation of receptor recycling; exocytosis; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; SNARE complex disassembly; transport; Golgi to plasma membrane protein transport; Golgi vesicle docking;
	Sources:Amigo / QuickGO
Orthologs
	4905
	18195
	ENSG00000073969; ENSG00000278174; ENSG00000276262
	ENSMUSG00000034187
	P46459
	P46460
	NM_006178
	NM_008740
	NP_006169
	NP_032766
	Wikidata
View/Edit Human	View/Edit Mouse

N-ethylmaleimide-sensitive factor, also known as NSF or N-ethylmaleimide sensitive fusion proteins, is an enzyme which in humans is encoded by the NSF gene.^[5]^[6]^[7]

^ ^a ^b ^c ENSG00000278174, ENSG00000276262 GRCh38: Ensembl release 89: ENSG00000073969, ENSG00000278174, ENSG00000276262 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000034187 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: NSF N-ethylmaleimide-sensitive factor".
^ Wilson DW, Whiteheart SW, Wiedmann M, Brunner M, Rothman JE (May 1992). "A multisubunit particle implicated in membrane fusion". The Journal of Cell Biology. 117 (3): 531–8. doi:10.1083/jcb.117.3.531. PMC 2289450. PMID 1315316.
^ Hoyle J, Phelan JP, Bermingham N, Fisher EM (Nov 1996). "Localization of human and mouse N-ethylmaleimide-sensitive factor (NSF) gene: a two-domain member of the AAA family that is involved in membrane fusion". Mammalian Genome. 7 (11): 850–2. doi:10.1007/s003359900249. PMID 8875895. S2CID 21435412.

[refGRCh38Ensembl-1] ENSG00000278174, ENSG00000276262 GRCh38: Ensembl release 89: ENSG00000073969, ENSG00000278174, ENSG00000276262 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000034187 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: NSF N-ethylmaleimide-sensitive factor".

[pmid1315316-6] Wilson DW, Whiteheart SW, Wiedmann M, Brunner M, Rothman JE (May 1992). "A multisubunit particle implicated in membrane fusion". The Journal of Cell Biology. 117 (3): 531–8. doi:10.1083/jcb.117.3.531. PMC 2289450. PMID 1315316.

[pmid8875895-7] Hoyle J, Phelan JP, Bermingham N, Fisher EM (Nov 1996). "Localization of human and mouse N-ethylmaleimide-sensitive factor (NSF) gene: a two-domain member of the AAA family that is involved in membrane fusion". Mammalian Genome. 7 (11): 850–2. doi:10.1007/s003359900249. PMID 8875895. S2CID 21435412.

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