NAPA (gene)

NAPA
Identifiers
Aliases	NAPA, SNSF attachment protein alpha
External IDs	OMIM: 603215; MGI: 104563; HomoloGene: 2839; GeneCards: NAPA; OMA:NAPA - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	47,515,091 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	16,117,975 bp
RNA expression pattern
	Top expressed in
	right hemisphere of cerebellum; ; primary visual cortex; ; superior frontal gyrus; ; prefrontal cortex; ; right frontal lobe; ; Brodmann area 9; ; right adrenal cortex; ; left adrenal cortex; ; pituitary gland; ; anterior cingulate cortex;
	Top expressed in
	dentate gyrus of hippocampal formation granule cell; ; superior frontal gyrus; ; neural layer of retina; ; primary visual cortex; ; motor neuron; ; muscle of thigh; ; cerebellar cortex; ; CA3 field; ; yolk sac; ; lip;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	soluble NSF attachment protein activity; protein binding; syntaxin binding; SNARE binding; protein-containing complex binding;
Cellular component	cytosol; membrane; vacuolar membrane; myelin sheath; terminal bouton; SNARE complex; synaptobrevin 2-SNAP-25-syntaxin-1a complex; extracellular exosome; Golgi membrane; plasma membrane; presynapse; postsynapse; glutamatergic synapse;
Biological process	SNARE complex disassembly; synaptic transmission, glutamatergic; membrane fusion; endoplasmic reticulum to Golgi vesicle-mediated transport; brain development; COPII vesicle coating; apical protein localization; neuron differentiation; protein transport; intracellular protein transport; intra-Golgi vesicle-mediated transport; vesicle-mediated transport; regulation of synaptic vesicle priming; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; positive regulation of ATP-dependent activity; transport; synaptic vesicle priming; protein-containing complex disassembly;
	Sources:Amigo / QuickGO
Orthologs
	8775
	108124
	ENSG00000105402
	ENSMUSG00000006024
	P54920
	Q9DB05
	NM_003827
	NM_025898
	NP_003818
	NP_080174
	Wikidata
View/Edit Human	View/Edit Mouse

N-ethylmaleimide-sensitive factor Attachment Protein Alpha, also known as SNAP-α, is a SNAP protein that is involved in the intra-cellular trafficking and fusing of vesicles to target membranes in cells.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000105402 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000006024 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Clary DO, Griff IC, Rothman JE (1990). "SNAPs, a family of NSF attachment proteins involved in intracellular membrane fusion in animals and yeast". Cell. 61 (4): 709–21. doi:10.1016/0092-8674(90)90482-t. PMID 2111733. S2CID 11468679.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000105402 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000006024 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Clary DO, Griff IC, Rothman JE (1990). "SNAPs, a family of NSF attachment proteins involved in intracellular membrane fusion in animals and yeast". Cell. 61 (4): 709–21. doi:10.1016/0092-8674(90)90482-t. PMID 2111733. S2CID 11468679.

[1]

[2]

[3]

[4]

[5]