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| NCAA Season 81 | |||||||||
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| One @ 81: Values Formation Through Sports | |||||||||
| Host school |  Colegio de San Juan de Letran | ||||||||
| General | |||||||||
| Seniors |  Benilde Blazers | ||||||||
| Juniors |  San Sebastian Staglets | ||||||||
| Seniors' champions | |||||||||
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| Juniors' champions | |||||||||
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| (NT) = No tournament; (DS) = Demonstration Sport; (Ex) = Exhibition; | |||||||||
NCAA Season 81 was the 2005–06 season of the National Collegiate Athletic Association (Philippines). Colegio de San Juan de Letran was the season's host.
To usher in the new season, Letran and the other NCAA member schools performed the opening ceremonies at the Araneta Coliseum, followed by four basketball games on June 25, 2005. Other disciplines started their own tournaments within the following months, with beach volleyball as the last tournament on mid-March.
De La Salle-College of Saint Benilde won its first General Championship honors for the Seniors division, while the San Sebastian Recoletos High School won its second Juniors General Championship, via tiebreakers, when La Salle Green Hills emerged with an equal number of points.