NDST3

NDST3
Identifiers
Aliases	NDST3, HSST3, N-deacetylase/N-sulfotransferase 3, N-deacetylase and N-sulfotransferase 3
External IDs	OMIM: 603950; MGI: 1932544; HomoloGene: 3513; GeneCards: NDST3; OMA:NDST3 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	118,258,634 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	123,484,502 bp
RNA expression pattern
	Top expressed in
	buccal mucosa cell; ; cerebellar cortex; ; cerebellar hemisphere; ; testicle; ; right hemisphere of cerebellum; ; prefrontal cortex; ; ganglionic eminence; ; nucleus accumbens; ; Brodmann area 9; ; right frontal lobe;
	Top expressed in
	cerebellar cortex; ; spermatid; ; primary visual cortex; ; seminiferous tubule; ; superior frontal gyrus; ; lumbar subsegment of spinal cord; ; neural layer of retina; ; inferior colliculi; ; dentate gyrus of hippocampal formation granule cell; ; cerebellar vermis;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; sulfotransferase activity; catalytic activity; hydrolase activity; [heparan sulfate-glucosamine N-sulfotransferase activity]; heparan sulfate N-acetylglucosaminyltransferase activity; deacetylase activity; heparan sulfate sulfotransferase activity;
Cellular component	integral component of membrane; Golgi membrane; Golgi apparatus; membrane; cellular component;
Biological process	metabolism; heparin biosynthetic process; heparan sulfate proteoglycan biosynthetic process; heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process; glycosaminoglycan biosynthetic process; sulfur compound metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	9348
	83398
	ENSG00000164100
	ENSMUSG00000027977
	O95803
	Q9EQH7
	NM_004784
	NM_001293682; NM_031186
	NP_004775
	NP_001280611; NP_112463
	Wikidata
View/Edit Human	View/Edit Mouse

Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3 is an enzyme that in humans is encoded by the NDST3 gene.^[5]^[6] It catalyses the reaction:

3'-phosphoadenylyl sulfate + α-D-glucosaminyl-[heparan sulfate]_(n) = adenosine 3',5'-bisphosphate + 2 H⁺ + N-sulfo-α-D-glucosaminyl-[heparan sulfate]_(n)^[7]

This is a step in the production of heparin.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000164100 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000027977 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Aikawa J, Esko JD (Mar 1999). "Molecular cloning and expression of a third member of the heparan sulfate/heparin GlcNAc N-deacetylase/ N-sulfotransferase family". J Biol Chem. 274 (5): 2690–5. doi:10.1074/jbc.274.5.2690. PMID 9915799.
^ "Entrez Gene: NDST3 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3".
^ ^a ^b "NDST3 – Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3 – Homo sapiens (Human) – NDST3 gene & protein". www.uniprot.org. Retrieved 2020-01-15.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000164100 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000027977 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9915799-5] Aikawa J, Esko JD (Mar 1999). "Molecular cloning and expression of a third member of the heparan sulfate/heparin GlcNAc N-deacetylase/ N-sulfotransferase family". J Biol Chem. 274 (5): 2690–5. doi:10.1074/jbc.274.5.2690. PMID 9915799.

[entrez-6] "Entrez Gene: NDST3 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3".

[:0-7] "NDST3 – Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3 – Homo sapiens (Human) – NDST3 gene & protein". www.uniprot.org. Retrieved 2020-01-15.

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