NEDD9

NEDD9
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2L81
Identifiers
Aliases	NEDD9, CAS-L, CAS2, CASL, CASS2, HEF1, neural precursor cell expressed, developmentally down-regulated 9
External IDs	OMIM: 602265; MGI: 97302; HomoloGene: 4669; GeneCards: NEDD9; OMA:NEDD9 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p24.2 Start 11,183,298 bp[1] End 11,382,348 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13|13 A3.3- A4 Start 41,463,057 bp[2] End 41,640,838 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lung lower lobe of lung glomerulus metanephric glomerulus upper lobe of lung upper lobe of left lung tail of epididymis parotid gland corpus epididymis caput epididymis Top expressed in cumulus cell left lung lobe Gonadal ridge granulocyte right lung lobe decidua gastrula left colon molar ciliary body More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding protein tyrosine kinase binding Cellular component cytoplasm cell junction Golgi apparatus spindle cell cortex spindle pole cell projection cytoskeleton nucleus focal adhesion lamellipodium nucleoplasm cytosol plasma membrane Biological process integrin-mediated signaling pathway regulation of growth cell cycle cell adhesion cytoskeleton organization signal transduction actin filament bundle assembly cell division positive regulation of cell migration positive regulation of protein tyrosine kinase activity positive regulation of substrate adhesion-dependent cell spreading cell migration actin filament reorganization activation of GTPase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4739 18003 Ensembl ENSG00000111859 ENSMUSG00000021365 UniProt Q14511 O35177 RefSeq (mRNA) NM_001142393 NM_001271033 NM_006403 NM_182966 NM_001111324 NM_017464 RefSeq (protein) NP_001135865 NP_001257962 NP_006394 NP_892011 NP_001104794 NP_059492 Location (UCSC) Chr 6: 11.18 – 11.38 Mb Chr 13: 41.46 – 41.64 Mb PubMed search [3] [4]
Wikidata
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Neural precursor cell expressed developmentally down-regulated protein 9 (NEDD-9) is a protein that in humans is encoded by the NEDD9 gene.^[5] NEDD-9 is also known as enhancer of filamentation 1 (EF1), CRK-associated substrate-related protein (CAS-L), and Cas scaffolding protein family member 2 (CASS2). An important paralog of this gene is BCAR1.