NEK2

NEK2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2JAV, 2W5A, 2W5B, 2WQO, 2XK3, 2XK4, 2XK6, 2XK7, 2XK8, 2XKC, 2XKD, 2XKE, 2XKF, 2XNM, 2XNN, 2XNO, 2XNP, 4A4X, 4AFE
Identifiers
Aliases	NEK2, HsPK21, NEK2A, NLK1, PPP1R111, RP67, NIMA related kinase 2
External IDs	OMIM: 604043; MGI: 109359; HomoloGene: 74441; GeneCards: NEK2; OMA:NEK2 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	211,675,630 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	191,565,162 bp
RNA expression pattern
	Top expressed in
	sperm; ; ventricular zone; ; secondary oocyte; ; left testis; ; right testis; ; gonad; ; ganglionic eminence; ; testicle; ; bone marrow; ; trabecular bone;
	Top expressed in
	spermatocyte; ; primary oocyte; ; spermatid; ; zygote; ; testicle; ; secondary oocyte; ; yolk sac; ; epiblast; ; bone marrow; ; morula;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; protein kinase activity; nucleotide binding; metal ion binding; kinase activity; protein serine/threonine kinase activity; protein binding; protein phosphatase binding; ATP binding;
Cellular component	cytosol; centrosome; spindle pole; chromosome; condensed nuclear chromosome; microtubule organizing center; midbody; nucleolus; microtubule; chromosome, centromeric region; cytoskeleton; kinetochore; nucleoplasm; nucleus; cytoplasm; protein-containing complex;
Biological process	positive regulation of telomere capping; regulation of mitotic centrosome separation; phosphorylation; chromosome segregation; negative regulation of DNA binding; positive regulation of telomere maintenance via telomerase; spindle assembly; cell division; protein phosphorylation; mitotic spindle assembly; G2/M transition of mitotic cell cycle; meiosis; positive regulation of telomerase activity; centrosome separation; mitotic sister chromatid segregation; protein autophosphorylation; cell cycle; negative regulation of centriole-centriole cohesion; regulation of attachment of spindle microtubules to kinetochore; blastocyst development; regulation of mitotic nuclear division; ciliary basal body-plasma membrane docking; mitotic cell cycle; regulation of G2/M transition of mitotic cell cycle;
	Sources:Amigo / QuickGO
Orthologs
	4751
	18005
	ENSG00000117650
	ENSMUSG00000026622
	P51955
	O35942
	NM_001204182; NM_001204183; NM_002497
	NM_010892
	NP_001191111; NP_001191112; NP_002488
	NP_035022
	Wikidata
View/Edit Human	View/Edit Mouse

Serine/threonine-protein kinase Nek2 is an enzyme that in humans is encoded by the NEK2 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000117650 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026622 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Schultz SJ, Nigg EA (Feb 1994). "Identification of 21 novel human protein kinases, including 3 members of a family related to the cell cycle regulator nimA of Aspergillus nidulans". Cell Growth Differ. 4 (10): 821–30. PMID 8274451.
^ "Entrez Gene: NEK2 NIMA (never in mitosis gene a)-related kinase 2".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000117650 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026622 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8274451-5] Schultz SJ, Nigg EA (Feb 1994). "Identification of 21 novel human protein kinases, including 3 members of a family related to the cell cycle regulator nimA of Aspergillus nidulans". Cell Growth Differ. 4 (10): 821–30. PMID 8274451.

[entrez-6] "Entrez Gene: NEK2 NIMA (never in mitosis gene a)-related kinase 2".

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