NFEPP

NFEPP
Clinical data
Drug class	Opioid
Legal status
Legal status	US: Schedule I;
Identifiers
	IUPAC name N-(3-Fluoro-1-phenethylpiperidin-4-yl)-N-phenylpropionamide;
CAS Number	1422952-84-8;
ChemSpider	58826238;
UNII	NXR38LA4PA;
CompTox Dashboard (EPA)	DTXSID101040109 ;
Chemical and physical data
Formula	C22H27FN2O
Molar mass	354.469 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCC(=O)N(c1ccccc1)[C@H]2CCN(C[C@H]2F)CCc3ccccc3;
	InChI InChI=1S/C22H27FN2O/c1-2-22(26)25(19-11-7-4-8-12-19)21-14-16-24(17-20(21)23)15-13-18-9-5-3-6-10-18/h3-12,20-21H,2,13-17H2,1H3/t20-,21+/m1/s1; Key:DMCQJJAWMFBPOX-RTWAWAEBSA-N;

NFEPP (N-(3-fluoro-1-phenethylpiperidin-4-yl)-N-phenylpropionamide) is an analgesic opioid chemical, similar in structure to fentanyl, designed in 2016 by Spahn et al. from Free University of Berlin^[2] to avoid the standard negative side effects of opiates, including opioid overdose, by only targeting inflamed tissue.^[3]^[4]

^ Drug Enforcement Administration Do (February 2018). "Schedules of Controlled Substances:Temporary Placement of Fentanyl-Related Substances in Schedule I. Temporary amendment; temporary scheduling order". Federal Register. 83 (25): 5188–92. PMID 29932611.
^ Spahn V, Del Vecchio G, Labuz D, Rodriguez-Gaztelumendi A, Massaly N, Temp J, et al. (March 2017). "A nontoxic pain killer designed by modeling of pathological receptor conformations". Science. 355 (6328): 966–969. Bibcode:2017Sci...355..966S. doi:10.1126/science.aai8636. PMID 28254944. S2CID 206653322.
^ Halford B (2017). "An opioid minus major side effects". Chemical & Engineering News. 95 (10): 8.
^ Edwards SR, Blough BE, Cowart K, Howell GH, Araujo AA, Haskell JP, et al. (May 2024). "Assessment of the Antinociceptive, Respiratory-Depressant, and Reinforcing Effects of the Low pKa Fluorinated Fentanyl Analogs, FF3 and NFEPP". Neuropharmacology. 255: 110002. doi:10.1016/j.neuropharm.2024.110002. PMID 38754577.