NFEPP

NFEPP
Clinical data
Drug classOpioid
Legal status
Legal status
Identifiers
  • N-(3-Fluoro-1-phenethylpiperidin-4-yl)-N-phenylpropionamide
CAS Number
ChemSpider
UNII
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC22H27FN2O
Molar mass354.469 g·mol−1
3D model (JSmol)
  • CCC(=O)N(c1ccccc1)[C@H]2CCN(C[C@H]2F)CCc3ccccc3
  • InChI=1S/C22H27FN2O/c1-2-22(26)25(19-11-7-4-8-12-19)21-14-16-24(17-20(21)23)15-13-18-9-5-3-6-10-18/h3-12,20-21H,2,13-17H2,1H3/t20-,21+/m1/s1
  • Key:DMCQJJAWMFBPOX-RTWAWAEBSA-N

NFEPP (N-(3-fluoro-1-phenethylpiperidin-4-yl)-N-phenylpropionamide) is an analgesic opioid chemical, similar in structure to fentanyl, designed in 2016 by Spahn et al. from Free University of Berlin[2] to avoid the standard negative side effects of opiates, including opioid overdose, by only targeting inflamed tissue.[3][4]

  1. ^ Drug Enforcement Administration Do (February 2018). "Schedules of Controlled Substances:Temporary Placement of Fentanyl-Related Substances in Schedule I. Temporary amendment; temporary scheduling order". Federal Register. 83 (25): 5188–92. PMID 29932611.
  2. ^ Spahn V, Del Vecchio G, Labuz D, Rodriguez-Gaztelumendi A, Massaly N, Temp J, et al. (March 2017). "A nontoxic pain killer designed by modeling of pathological receptor conformations". Science. 355 (6328): 966–969. Bibcode:2017Sci...355..966S. doi:10.1126/science.aai8636. PMID 28254944. S2CID 206653322.
  3. ^ Halford B (2017). "An opioid minus major side effects". Chemical & Engineering News. 95 (10): 8.
  4. ^ Edwards SR, Blough BE, Cowart K, Howell GH, Araujo AA, Haskell JP, et al. (May 2024). "Assessment of the Antinociceptive, Respiratory-Depressant, and Reinforcing Effects of the Low pKa Fluorinated Fentanyl Analogs, FF3 and NFEPP". Neuropharmacology: 110002. doi:10.1016/j.neuropharm.2024.110002. PMID 38754577.