NKG2D

KLRK1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1KCG, 4PDC, 1HYR, 1MPU, 4S0U
Identifiers
Aliases	KLRK1, CD314, D12S2489E, KLR, NKG2-D, NKG2D, natural killer group 2D, killer cell lectin-like receptor K1, killer cell lectin like receptor K1
External IDs	OMIM: 611817; MGI: 1196250; HomoloGene: 136440; GeneCards: KLRK1; OMA:KLRK1 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	10,391,874 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	129,600,827 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; spleen; ; lymph node; ; blood; ; appendix; ; gallbladder; ; upper lobe of left lung; ; mucosa of transverse colon; ; bone marrow; ; testicle;
	Top expressed in
	superior surface of tongue; ; gallbladder; ; plantaris muscle; ; extensor digitorum longus muscle; ; morula; ; spleen; ; corneal stroma; ; mesenteric lymph nodes; ; granulocyte; ; interventricular septum;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein homodimerization activity; protein binding; MHC class Ib receptor activity; MHC class I protein binding; carbohydrate binding; signaling receptor activity; kinase binding;
Cellular component	integral component of membrane; membrane; integral component of plasma membrane; cell surface; external side of plasma membrane; plasma membrane;
Biological process	cell differentiation; adaptive immune response; immune system process; positive regulation of nitric oxide biosynthetic process; negative regulation of natural killer cell chemotaxis; T cell costimulation; natural killer cell activation; positive regulation of interferon-gamma production; stimulatory C-type lectin receptor signaling pathway; negative regulation of GTPase activity; regulation of immune response; cellular response to lipopolysaccharide; positive regulation of natural killer cell mediated cytotoxicity; signal transduction; defense response to Gram-positive bacterium; innate immune response; natural killer cell mediated cytotoxicity; positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target; positive regulation of myeloid dendritic cell activation; positive regulation of apoptotic process;
	Sources:Amigo / QuickGO
Orthologs
	22914
	27007
	ENSG00000213809
	ENSMUSG00000030149
	P26718
	O54709
	NM_007360
	NM_001083322; NM_001286018; NM_033078
	NP_001186734
	NP_001076791; NP_001272947; NP_149069
	Wikidata
View/Edit Human	View/Edit Mouse

NKG2D is an activating receptor (transmembrane protein) belonging to the NKG2 family of C-type lectin-like receptors.^[5] NKG2D is encoded by KLRK1 (killer cell lectin like receptor K1) gene which is located in the NK-gene complex (NKC) situated on chromosome 6 in mice^[6] and chromosome 12 in humans.^[7] In mice, it is expressed by NK cells, NK1.1⁺ T cells, γδ T cells, activated CD8⁺ αβ T cells and activated macrophages.^[8] In humans, it is expressed by NK cells, γδ T cells and CD8⁺ αβ T cells.^[9] NKG2D recognizes induced-self proteins from MIC and RAET1/ULBP families which appear on the surface of stressed, malignant transformed, and infected cells.^[10]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000213809 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000030149 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Houchins JP, Yabe T, McSherry C, Bach FH (April 1991). "DNA sequence analysis of NKG2, a family of related cDNA clones encoding type II integral membrane proteins on human natural killer cells". The Journal of Experimental Medicine. 173 (4): 1017–20. doi:10.1084/jem.173.4.1017. PMC 2190798. PMID 2007850.
^ Brown MG, Fulmek S, Matsumoto K, Cho R, Lyons PA, Levy ER, et al. (May 1997). "A 2-Mb YAC contig and physical map of the natural killer gene complex on mouse chromosome 6". Genomics. 42 (1): 16–25. doi:10.1006/geno.1997.4721. PMID 9177771.
^ Yabe T, McSherry C, Bach FH, Fisch P, Schall RP, Sondel PM, Houchins JP (1993). "A multigene family on human chromosome 12 encodes natural killer-cell lectins". Immunogenetics. 37 (6): 455–60. doi:10.1007/BF00222470. PMID 8436421. S2CID 27350036.
^ Jamieson AM, Diefenbach A, McMahon CW, Xiong N, Carlyle JR, Raulet DH (July 2002). "The role of the NKG2D immunoreceptor in immune cell activation and natural killing". Immunity. 17 (1): 19–29. doi:10.1016/S1074-7613(02)00333-3. PMID 12150888.
^ Bauer S, Groh V, Wu J, Steinle A, Phillips JH, Lanier LL, Spies T (July 1999). "Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA". Science. 285 (5428): 727–9. doi:10.1126/science.285.5428.727. PMID 10426993.
^ Raulet DH (October 2003). "Roles of the NKG2D immunoreceptor and its ligands". Nature Reviews. Immunology. 3 (10): 781–90. doi:10.1038/nri1199. PMID 14523385. S2CID 18234848.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000213809 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000030149 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2007850-5] Houchins JP, Yabe T, McSherry C, Bach FH (April 1991). "DNA sequence analysis of NKG2, a family of related cDNA clones encoding type II integral membrane proteins on human natural killer cells". The Journal of Experimental Medicine. 173 (4): 1017–20. doi:10.1084/jem.173.4.1017. PMC 2190798. PMID 2007850.

[pmid_9177771-6] Brown MG, Fulmek S, Matsumoto K, Cho R, Lyons PA, Levy ER, et al. (May 1997). "A 2-Mb YAC contig and physical map of the natural killer gene complex on mouse chromosome 6". Genomics. 42 (1): 16–25. doi:10.1006/geno.1997.4721. PMID 9177771.

[pmid8436421-7] Yabe T, McSherry C, Bach FH, Fisch P, Schall RP, Sondel PM, Houchins JP (1993). "A multigene family on human chromosome 12 encodes natural killer-cell lectins". Immunogenetics. 37 (6): 455–60. doi:10.1007/BF00222470. PMID 8436421. S2CID 27350036.

[pmid_12150888-8] Jamieson AM, Diefenbach A, McMahon CW, Xiong N, Carlyle JR, Raulet DH (July 2002). "The role of the NKG2D immunoreceptor in immune cell activation and natural killing". Immunity. 17 (1): 19–29. doi:10.1016/S1074-7613(02)00333-3. PMID 12150888.

[pmid10426993-9] Bauer S, Groh V, Wu J, Steinle A, Phillips JH, Lanier LL, Spies T (July 1999). "Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA". Science. 285 (5428): 727–9. doi:10.1126/science.285.5428.727. PMID 10426993.

[pmid14523385-10] Raulet DH (October 2003). "Roles of the NKG2D immunoreceptor and its ligands". Nature Reviews. Immunology. 3 (10): 781–90. doi:10.1038/nri1199. PMID 14523385. S2CID 18234848.

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