NL-201

NL-201 was an immunotherapy drug candidate that underwent a Phase 1 human clinical trial in cancer patients.[1] It is a de novo protein that was first computationally designed at the Institute of Protein Design (IPD), University of Washington.[2] In November 2022, Neoleukin Therapeutics announced it would discontinue the development of NL-201.[3]

  1. ^ Neoleukin Therapeutics, Inc. (2021-05-25). "A First-in-Human Phase 1 Study of NL-201 in Patients With Relapsed or Refractory Cancer". {{cite journal}}: Cite journal requires |journal= (help)
  2. ^ Silva, Daniel-Adriano; Yu, Shawn; Ulge, Umut Y.; Spangler, Jamie B.; Jude, Kevin M.; Labão-Almeida, Carlos; Ali, Lestat R.; Quijano-Rubio, Alfredo; Ruterbusch, Mikel; Leung, Isabel; Biary, Tamara (2019-01-09). "De novo design of potent and selective mimics of IL-2 and IL-15". Nature. 565 (7738): 186–191. Bibcode:2019Natur.565..186S. doi:10.1038/s41586-018-0830-7. ISSN 1476-4687. PMC 6521699. PMID 30626941.
  3. ^ "Neoleukin Therapeutics Announces Third Quarter 2022 Financial Results and Corporate Update". 2022-11-14.