NLRP3

NLRP3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3QF2, 2NAQ
Identifiers
Aliases	NLRP3, AGTAVPRL, AII, AVP, C1orf7, CIAS1, CLR1.1, FCAS, FCAS1, FCU, MWS, NALP3, PYPAF1, NLR family, pyrin domain containing 3, NLR family pyrin domain containing 3, DFNA34, KEFH
External IDs	OMIM: 606416; MGI: 2653833; HomoloGene: 3600; GeneCards: NLRP3; OMA:NLRP3 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q44 Start 247,416,156 bp[1] End 247,449,108 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 B1.3 Start 59,432,394 bp[2] End 59,457,782 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte granulocyte blood bone marrow cells gallbladder testicle right lung appendix upper lobe of left lung spleen Top expressed in granulocyte blood stroma of bone marrow morula calvaria spleen submandibular gland gastrula olfactory epithelium meninges More reference expression data BioGPS More reference expression data
Gene ontology Molecular function sequence-specific DNA binding nucleotide binding transcription factor binding protein binding peptidoglycan binding ATP binding identical protein binding Cellular component cytoplasm cytosol extracellular region endoplasmic reticulum inflammasome complex nucleus NLRP3 inflammasome complex Golgi membrane Golgi apparatus membrane Biological process defense response detection of biotic stimulus NLRP3 inflammasome complex assembly regulation of transcription, DNA-templated negative regulation of acute inflammatory response positive regulation of interleukin-5 production interleukin-18 production immune system process positive regulation of interleukin-4 production transcription, DNA-templated positive regulation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of interleukin-13 production positive regulation of T-helper 17 cell differentiation defense response to virus protein complex oligomerization positive regulation of T-helper 2 cell differentiation regulation of inflammatory response interleukin-1 beta production positive regulation of type 2 immune response inflammatory response negative regulation of NF-kappaB transcription factor activity activation of cysteine-type endopeptidase activity involved in apoptotic process negative regulation of inflammatory response cellular response to lipopolysaccharide positive regulation of T-helper 2 cell cytokine production signal transduction positive regulation of transcription by RNA polymerase II apoptotic process innate immune response protein deubiquitination defense response to Gram-positive bacterium positive regulation of NF-kappaB transcription factor activity cellular response to peptidoglycan negative regulation of NIK/NF-kappaB signaling Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 114548 216799 Ensembl ENSG00000162711 ENSMUSG00000032691 UniProt Q96P20 Q8R4B8 RefSeq (mRNA) NM_001079821 NM_001127461 NM_001127462 NM_001243133 NM_004895 NM_183395 NM_145827 NM_001359638 RefSeq (protein) NP_001073289 NP_001120933 NP_001120934 NP_001230062 NP_004886 NP_899632 NP_665826 NP_001346567 Location (UCSC) Chr 1: 247.42 – 247.45 Mb Chr 11: 59.43 – 59.46 Mb PubMed search [3] [4]
Wikidata
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NLR family pyrin domain containing 3 (NLRP3) (previously known as NACHT, LRR, and PYD domains-containing protein 3 [NALP3] and cryopyrin), is a protein that in humans is encoded by the NLRP3 gene^[5] located on the long arm of chromosome 1.^[6]

NLRP3 is expressed predominantly in macrophages and as a component of the inflammasome,^{[7][8]: 436} detects products of damaged cells such as extracellular ATP and crystalline uric acid. Activated NLRP3 in turn triggers an immune response. Mutations in the NLRP3 gene are associated with a number of organ specific autoimmune diseases.