NOL1

NOP2
Identifiers
Aliases	NOP2, NOL1, NOP120, NSUN1, p120, NOP2 nucleolar protein
External IDs	OMIM: 164031; MGI: 107891; HomoloGene: 135865; GeneCards: NOP2; OMA:NOP2 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	6,568,691 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	125,121,716 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; lymph node; ; appendix; ; spleen; ; left uterine tube; ; gastrocnemius muscle; ; islet of Langerhans; ; right lobe of thyroid gland; ; anterior pituitary; ; tonsil;
	Top expressed in
	epiblast; ; otic placode; ; otic vesicle; ; morula; ; morula; ; superior surface of tongue; ; gallbladder; ; somite; ; embryo; ; embryo;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	methyltransferase activity; transferase activity; protein binding; S-adenosylmethionine-dependent methyltransferase activity; rRNA (cytosine-C5-)-methyltransferase activity; RNA binding;
Cellular component	nucleus; nucleolus; nucleoplasm;
Biological process	rRNA processing; methylation; rRNA base methylation; maturation of LSU-rRNA; positive regulation of cell population proliferation; regulation of transcription by RNA polymerase II; ribosomal large subunit assembly; regulation of signal transduction by p53 class mediator; ribosome biogenesis;
	Sources:Amigo / QuickGO
Orthologs
	4839
	110109
	ENSG00000111641
	ENSMUSG00000038279
	P46087
	Q922K7
	NM_001033714; NM_001258308; NM_001258309; NM_001258310; NM_006170
	NM_138747
	NP_001028886; NP_001245237; NP_001245238; NP_001245239; NP_006161
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Putative ribosomal RNA methyltransferase NOP2 is an enzyme that in humans is encoded by the NOP2 gene.^[5]^[6]

The protein encoded by this gene is a nucleolar antigen expressed in proliferating cells. It is not detectable in non-proliferating normal tissue but is detectable in many human tumors.^[7]

Overexpression of p120 leads to malignant transformation of 3T3 cells while treatment with antisense p120 mRNA causes the transformed cells to revert to their original non-malignant phenotype.^[8] The p120 protein displays a dramatic increase in expression at the G1/S transition suggesting that p120 regulates the cell cycle and nucleolar activity that is required for cell proliferation.^[9]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000111641 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000038279 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Baens M, Chaffanet M, Aerssens J, Cassiman JJ, Marynen P (October 1994). "Assignment of the gene for the human proliferating cell nucleolar protein P120 (NOL1) to chromosome 12p13 by fluorescence in situ hybridization and polymerase chain reaction with somatic cell hybrids". Genomics. 21 (1): 296–7. doi:10.1006/geno.1994.1267. PMID 8088812.
^ "Entrez Gene: NOL1 nucleolar protein 1, 120kDa".
^ Freeman JW, Busch RK, Gyorkey F, Gyorkey P, Ross BE, Busch H (1 March 1988). "Identification and characterization of a human proliferation-associated nucleolar antigen with a molecular weight of 120,000 expressed in early G1 phase". Cancer Res. 48 (5): 1244–51. PMID 3422591.
^ Perlaky L, Valdez BC, Busch RK, Larson RG, Jhiang SM, Zhang WW, Brattain M, Busch H (January 1992). "Increased growth of NIH/3T3 cells by transfection with human p120 complementary DNA and inhibition by a p120 antisense construct". Cancer Res. 52 (2): 428–36. PMID 1728415.
^ Fonagy A, Swiderski C, Wilson A, Bolton W, Kenyon N, Freeman JW (January 1993). "Cell cycle regulated expression of nucleolar antigen P120 in normal and transformed human fibroblasts". J. Cell. Physiol. 154 (1): 16–27. doi:10.1002/jcp.1041540104. PMID 8419402. S2CID 45238441.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000111641 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000038279 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8088812-5] Baens M, Chaffanet M, Aerssens J, Cassiman JJ, Marynen P (October 1994). "Assignment of the gene for the human proliferating cell nucleolar protein P120 (NOL1) to chromosome 12p13 by fluorescence in situ hybridization and polymerase chain reaction with somatic cell hybrids". Genomics. 21 (1): 296–7. doi:10.1006/geno.1994.1267. PMID 8088812.

[entrez-6] "Entrez Gene: NOL1 nucleolar protein 1, 120kDa".

[pmid3422591-7] Freeman JW, Busch RK, Gyorkey F, Gyorkey P, Ross BE, Busch H (1 March 1988). "Identification and characterization of a human proliferation-associated nucleolar antigen with a molecular weight of 120,000 expressed in early G1 phase". Cancer Res. 48 (5): 1244–51. PMID 3422591.

[pmid1728415-8] Perlaky L, Valdez BC, Busch RK, Larson RG, Jhiang SM, Zhang WW, Brattain M, Busch H (January 1992). "Increased growth of NIH/3T3 cells by transfection with human p120 complementary DNA and inhibition by a p120 antisense construct". Cancer Res. 52 (2): 428–36. PMID 1728415.

[pmid8419402-9] Fonagy A, Swiderski C, Wilson A, Bolton W, Kenyon N, Freeman JW (January 1993). "Cell cycle regulated expression of nucleolar antigen P120 in normal and transformed human fibroblasts". J. Cell. Physiol. 154 (1): 16–27. doi:10.1002/jcp.1041540104. PMID 8419402. S2CID 45238441.

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