NONOate

The structure of a typical NONOate group

In chemistry, a NONOate is a compound having the chemical formula R1R2N−(NO)−N=O, where R1 and R2 are alkyl groups. One example for this is 1,1-diethyl-2-hydroxy-2-nitrosohydrazine, or diethylamine dinitric oxide. These compounds are unusual in having three sequential nitrogen atoms: an amine functional group, a bridging NO group, and a terminal nitrosyl group. In contact with water, these compounds release NO (nitric oxide).[1][2]

  1. ^ L. A. Sheffler; D. A. Wink; G. Melillo; G. W. Cox (January 1, 1995). "Characterization of nitric oxide-stimulated ADP-ribosylation of various proteins from the mouse macrophage cell line ANA-1 using sodium nitroprusside and the novel nitric oxide-donating compound diethylamine dinitric oxide". Journal of Leukocyte Biology. 57 (1): 152–159. PMID 7530278. Archived from the original on September 27, 2007. Retrieved April 25, 2007.
  2. ^ Joseph A. Hrabie; John R. Klose; David A. Wink; Larry K. Keefer (1993). "New nitric oxide-releasing zwitterions derived from polyamines". J. Org. Chem. 58 (6): 1472–1476. doi:10.1021/jo00058a030.