NOTCH3

NOTCH3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4ZLP, 5CZX, 5CZV
Identifiers
Aliases	NOTCH3, CADASIL, CASIL, IMF2, LMNS, CADASIL1, notch 3, notch receptor 3
External IDs	OMIM: 600276; MGI: 99460; HomoloGene: 376; GeneCards: NOTCH3; OMA:NOTCH3 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	15,200,995 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	32,385,826 bp
RNA expression pattern
	Top expressed in
	popliteal artery; ; tibial arteries; ; right coronary artery; ; ventricular zone; ; Descending thoracic aorta; ; ascending aorta; ; left coronary artery; ; saphenous vein; ; skin of leg; ; stromal cell of endometrium;
	Top expressed in
	external carotid artery; ; corneal stroma; ; internal carotid artery; ; ankle joint; ; molar; ; vas deferens; ; Gonadal ridge; ; left lung lobe; ; lactiferous gland; ; carotid body;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; protein binding; enzyme binding; cadherin binding; identical protein binding; signaling receptor activity;
Cellular component	integral component of membrane; endoplasmic reticulum membrane; membrane; Golgi membrane; receptor complex; plasma membrane; nucleoplasm; extracellular region; actin cytoskeleton; nucleus; cytosol; cell surface;
Biological process	Notch signaling pathway; cell differentiation; regulation of transcription, DNA-templated; negative regulation of neuron differentiation; negative regulation of cell differentiation; glomerular capillary formation; negative regulation of transcription by RNA polymerase II; transcription, DNA-templated; multicellular organism development; artery morphogenesis; forebrain development; neuron fate commitment; transcription initiation from RNA polymerase II promoter; positive regulation of transcription by RNA polymerase II; positive regulation of smooth muscle cell proliferation; regulation of developmental process; positive regulation of transcription of Notch receptor target; Notch receptor processing, ligand-dependent; negative regulation of Notch signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	4854
	18131
	ENSG00000074181
	ENSMUSG00000038146
	Q9UM47
	Q61982
	NM_000435
	NM_008716
	NP_000426
	NP_032742
	Wikidata
View/Edit Human	View/Edit Mouse

Neurogenic locus notch homolog protein 3 (Notch 3) is a protein that in humans is encoded by the NOTCH3 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000074181 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000038146 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Sugaya K, Fukagawa T, Matsumoto K, Mita K, Takahashi E, Ando A, Inoko H, Ikemura T (September 15, 1994). "Three genes in the human MHC class III region near the junction with the class II: gene for receptor of advanced glycosylation end products, PBX2 homeobox gene and a notch homolog, human counterpart of mouse mammary tumor gene int-3". Genomics. 23 (2): 408–19. doi:10.1006/geno.1994.1517. PMID 7835890.
^ "Entrez Gene: NOTCH3 Notch homolog 3 (Drosophila)".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000074181 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000038146 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7835890-5] Sugaya K, Fukagawa T, Matsumoto K, Mita K, Takahashi E, Ando A, Inoko H, Ikemura T (September 15, 1994). "Three genes in the human MHC class III region near the junction with the class II: gene for receptor of advanced glycosylation end products, PBX2 homeobox gene and a notch homolog, human counterpart of mouse mammary tumor gene int-3". Genomics. 23 (2): 408–19. doi:10.1006/geno.1994.1517. PMID 7835890.

[entrez-6] "Entrez Gene: NOTCH3 Notch homolog 3 (Drosophila)".

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