NOX4

NOX4
Identifiers
Aliases	NOX4, KOX, KOX-1, RENOX, NADPH oxidase 4
External IDs	OMIM: 605261; MGI: 1354184; HomoloGene: 41065; GeneCards: NOX4; OMA:NOX4 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	89,498,187 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	87,047,918 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; kidney tubule; ; glomerulus; ; metanephric glomerulus; ; ascending aorta; ; human kidney; ; Descending thoracic aorta; ; pericardium; ; popliteal artery; ; tibial arteries;
	Top expressed in
	human kidney; ; tunica media of zone of aorta; ; right kidney; ; lumbar spinal ganglion; ; epithelium of small intestine; ; left lobe of liver; ; ascending aorta; ; carotid body; ; aortic valve; ; renal cortex;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; NAD(P)H oxidase H2O2-forming activity; flavin adenine dinucleotide binding; oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor; modified amino acid binding; protein binding; heme binding; electron transfer activity; oxidoreductase activity; oxygen gasoreceptor activity; superoxide-generating NAD(P)H oxidase activity; protein tyrosine kinase binding;
Cellular component	integral component of membrane; membrane; focal adhesion; plasma membrane; stress fiber; cell junction; NADPH oxidase complex; nucleolus; apical plasma membrane; mitochondrion; endoplasmic reticulum; perinuclear region of cytoplasm; cell periphery; endoplasmic reticulum membrane; nucleus; perinuclear endoplasmic reticulum;
Biological process	cellular response to transforming growth factor beta stimulus; positive regulation of protein kinase B signaling; response to hypoxia; gene expression; positive regulation of MAP kinase activity; cardiac muscle cell differentiation; ageing; bone resorption; reactive oxygen species metabolic process; superoxide anion generation; positive regulation of smooth muscle cell migration; positive regulation of reactive oxygen species metabolic process; cellular response to gamma radiation; cell morphogenesis; positive regulation of DNA biosynthetic process; positive regulation of ERK1 and ERK2 cascade; positive regulation of apoptotic process; homocysteine metabolic process; inflammatory response; positive regulation of stress fiber assembly; cellular response to cAMP; cellular response to glucose stimulus; superoxide metabolic process; negative regulation of cell population proliferation; cellular response to oxidative stress; electron transport chain; heart process; positive regulation of protein tyrosine kinase activity; reactive oxygen species biosynthetic process; defense response;
	Sources:Amigo / QuickGO
Orthologs
	50507
	50490
	ENSG00000086991
	ENSMUSG00000030562
	Q9NPH5
	Q9JHI8
NM_001143836; NM_001143837; NM_001291926; NM_001291927; NM_001291929;
	NM_001300995; NM_016931
	NM_001285833; NM_001285835; NM_015760
NP_001137308; NP_001137309; NP_001278855; NP_001278856; NP_001278858;
	NP_001287924; NP_058627
	NP_001272762; NP_001272764; NP_056575
	Wikidata
View/Edit Human	View/Edit Mouse

NADPH oxidase 4 is an enzyme that in humans is encoded by the NOX4 gene, and is a member of the NOX family of NADPH oxidases.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000086991 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000030562 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Cite error: The named reference entrez was invoked but never defined (see the help page).

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000086991 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000030562 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] Cite error: The named reference entrez was invoked but never defined (see the help page).

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