NPEPPS

NPEPPS
Identifiers
Aliases	NPEPPS, AAP-S, MP100, PSA, aminopeptidase puromycin sensitive
External IDs	OMIM: 606793; MGI: 1101358; HomoloGene: 36199; GeneCards: NPEPPS; OMA:NPEPPS - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	47,624,665 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	97,171,464 bp
RNA expression pattern
	Top expressed in
	right hemisphere of cerebellum; ; vagina; ; epithelium of colon; ; ganglionic eminence; ; skin of leg; ; gastric mucosa; ; muscle of thigh; ; skin of abdomen; ; left ovary; ; right ovary;
	Top expressed in
	Rostral migratory stream; ; neural layer of retina; ; retinal pigment epithelium; ; ciliary body; ; facial motor nucleus; ; granulocyte; ; supraoptic nucleus; ; dentate gyrus of hippocampal formation granule cell; ; nucleus of stria terminalis; ; anterior horn of spinal cord;
	More reference expression data
	n/a
Gene ontology
Molecular function	peptide binding; zinc ion binding; peptidase activity; metalloaminopeptidase activity; metallopeptidase activity; hydrolase activity; metal ion binding; aminopeptidase activity;
Cellular component	extracellular exosome; nucleus; cytosol; cytoplasm;
Biological process	protein polyubiquitination; cellular response to hypoxia; positive regulation of protein targeting to mitochondrion; peptide catabolic process; proteolysis;
	Sources:Amigo / QuickGO
Orthologs
	9520
	19155
	ENSG00000141279
	ENSMUSG00000001441
	P55786
	Q11011
	NM_006310; NM_001330257
	NM_008942
	NP_001317186; NP_006301
	NP_032968
	Wikidata
View/Edit Human	View/Edit Mouse

Puromycin-sensitive amino peptidase also known as cytosol alanyl aminopeptidase or alanine aminopeptidase (AAP) (EC 3.4.11.14) is an enzyme that in humans is encoded by the NPEPPS gene.^[5]^[6]^[7] It is used as a biomarker to detect damage to the kidneys, and that may be used to help diagnose certain kidney disorders. It is found at high levels in the urine when there are kidney problems.^[8]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000141279 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000001441 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Tobler AR, Constam DB, Schmitt-Gräff A, Malipiero U, Schlapbach R, Fontana A (March 1997). "Cloning of the human puromycin-sensitive aminopeptidase and evidence for expression in neurons". Journal of Neurochemistry. 68 (3): 889–97. doi:10.1046/j.1471-4159.1997.68030889.x. PMID 9048733. S2CID 30408265.
^ Thompson MW, Tobler A, Fontana A, Hersh LB (May 1999). "Cloning and analysis of the gene for the human puromycin-sensitive aminopeptidase". Biochemical and Biophysical Research Communications. 258 (2): 234–40. doi:10.1006/bbrc.1999.0604. PMID 10329370.
^ "Entrez Gene: NPEPPS aminopeptidase puromycin sensitive".
^ Holdt B, Peters E, Nagel HR, Steiner M (2008). "An automated assay of urinary alanine aminopeptidase activity". Clinical Chemistry and Laboratory Medicine. 46 (4): 537–40. doi:10.1515/CCLM.2008.103. PMID 18302530. S2CID 45057277.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000141279 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000001441 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9048733-5] Tobler AR, Constam DB, Schmitt-Gräff A, Malipiero U, Schlapbach R, Fontana A (March 1997). "Cloning of the human puromycin-sensitive aminopeptidase and evidence for expression in neurons". Journal of Neurochemistry. 68 (3): 889–97. doi:10.1046/j.1471-4159.1997.68030889.x. PMID 9048733. S2CID 30408265.

[pmid10329370-6] Thompson MW, Tobler A, Fontana A, Hersh LB (May 1999). "Cloning and analysis of the gene for the human puromycin-sensitive aminopeptidase". Biochemical and Biophysical Research Communications. 258 (2): 234–40. doi:10.1006/bbrc.1999.0604. PMID 10329370.

[entrez-7] "Entrez Gene: NPEPPS aminopeptidase puromycin sensitive".

[pmid18302530-8] Holdt B, Peters E, Nagel HR, Steiner M (2008). "An automated assay of urinary alanine aminopeptidase activity". Clinical Chemistry and Laboratory Medicine. 46 (4): 537–40. doi:10.1515/CCLM.2008.103. PMID 18302530. S2CID 45057277.

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