NPM1

NPM1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2LLH, 2P1B, 2VXD
Identifiers
Aliases	NPM1, B23, NPM, nucleophosmin (nucleolar phosphoprotein B23, numatrin), nucleophosmin, nucleophosmin 1
External IDs	OMIM: 164040; MGI: 106184; HomoloGene: 81697; GeneCards: NPM1; OMA:NPM1 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q35.1 Start 171,387,116 bp[1] End 171,411,810 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 A4 Start 33,102,287 bp[2] End 33,113,206 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon left ovary ventricular zone right ovary canal of the cervix body of uterus ganglionic eminence body of pancreas right uterine tube ectocervix Top expressed in tail of embryo epiblast genital tubercle morula embryo primary oocyte zygote secondary oocyte embryo blastocyst More reference expression data BioGPS More reference expression data
Gene ontology Molecular function ribosomal large subunit binding protein homodimerization activity ribosomal small subunit binding unfolded protein binding transcription coactivator activity protein kinase inhibitor activity histone binding Tat protein binding NF-kappaB binding protein binding RNA binding protein heterodimerization activity nucleic acid binding protein kinase binding transcription factor binding rRNA binding protein N-terminus binding chromatin binding Cellular component cytoplasm membrane focal adhesion spindle pole centrosome nucleoplasm microtubule organizing center nucleolus cytoskeleton nucleus protein-DNA complex granular component centrosome cytosol large ribosomal subunit small ribosomal subunit nuclear speck protein-containing complex ribonucleoprotein complex Biological process centrosome cycle regulation of eIF2 alpha phosphorylation by dsRNA positive regulation of cell cycle G2/M phase transition negative regulation of centrosome duplication regulation of centriole replication response to stress positive regulation of translation CENP-A containing chromatin assembly positive regulation of transcription, DNA-templated positive regulation of NF-kappaB transcription factor activity protein complex oligomerization negative regulation of protein kinase activity by regulation of protein phosphorylation regulation of endodeoxyribonuclease activity regulation of endoribonuclease activity ribosome assembly intracellular protein transport DNA repair signal transduction negative regulation of cell population proliferation nucleosome assembly viral process DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest regulation of transcription by RNA polymerase II cellular response to UV ribosomal large subunit export from nucleus ribosomal small subunit export from nucleus rRNA export from nucleus cell volume homeostasis nucleocytoplasmic transport protein localization positive regulation of cell population proliferation posttranscriptional regulation of gene expression negative regulation of gene expression regulation of centrosome duplication positive regulation of centrosome duplication cell growth positive regulation of cellular biosynthetic process positive regulation of protein ubiquitination regulation of protein stability ribosomal large subunit biogenesis ribosomal small subunit biogenesis negative regulation of apoptotic process regulation of DNA damage response, signal transduction by p53 class mediator positive regulation of protein kinase activity positive regulation of transcription by RNA polymerase II negative regulation of mRNA splicing, via spliceosome protein stabilization protein homooligomerization regulation of cell cycle positive regulation of protein localization to nucleolus chromatin remodeling regulation of mRNA stability involved in cellular response to UV Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4869 18148 Ensembl ENSG00000181163 ENSMUSG00000057113 UniProt P06748 Q61937 RefSeq (mRNA) NM_001037738 NM_002520 NM_199185 NM_001355006 NM_001355009 NM_001355007 NM_001355010 NM_001252260 NM_001252261 NM_008722 RefSeq (protein) NP_001032827 NP_002511 NP_954654 NP_001341935 NP_001341938 NP_001341936 NP_001341939 NP_001239189 NP_001239190 NP_032748 Location (UCSC) Chr 5: 171.39 – 171.41 Mb Chr 11: 33.1 – 33.11 Mb PubMed search [3] [4]
Wikidata
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Nucleophosmin (NPM), also known as nucleolar phosphoprotein B23 or numatrin, is a protein that in humans is encoded by the NPM1 gene.^[5][6]