NPR3

NPR3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1JDN, 1JDP, 1YK0, 1YK1
Identifiers
Aliases	NPR3, ANP-C, ANPR-C, ANPRC, C5orf23, GUCY2B, NPR-C, NPRC, natriuretic peptide receptor 3, BOMOS
External IDs	OMIM: 108962; MGI: 97373; HomoloGene: 699; GeneCards: NPR3; OMA:NPR3 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	32,791,724 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	11,907,373 bp
RNA expression pattern
	Top expressed in
	glomerulus; ; metanephric glomerulus; ; kidney tubule; ; cardiac muscle tissue of right atrium; ; stromal cell of endometrium; ; renal medulla; ; human kidney; ; myocardium of left ventricle; ; visceral pleura; ; lower lobe of lung;
	Top expressed in
	atrioventricular valve; ; white adipose tissue; ; atrium; ; left lung lobe; ; right lung lobe; ; Epithelium of choroid plexus; ; choroidal fissure; ; ankle; ; brown adipose tissue; ; lactiferous gland;
	More reference expression data
	n/a
Gene ontology
Molecular function	hormone binding; natriuretic peptide receptor activity; G protein-coupled peptide receptor activity; protein binding; chloride ion binding; peptide binding; protein homodimerization activity; peptide hormone binding;
Cellular component	integral component of membrane; membrane; integral component of plasma membrane; intracellular anatomical structure; extracellular exosome; protein-containing complex;
Biological process	skeletal system development; negative regulation of smooth muscle cell proliferation; positive regulation of urine volume; pancreatic juice secretion; regulation of osteoblast proliferation; regulation of blood pressure; phospholipase C-activating G protein-coupled receptor signaling pathway; positive regulation of nitric-oxide synthase activity; phosphatidylinositol-mediated signaling; osteoclast proliferation; negative regulation of adenylate cyclase activity; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; negative regulation of cold-induced thermogenesis;
	Sources:Amigo / QuickGO
Orthologs
	4883
	18162
	ENSG00000113389
	ENSMUSG00000022206
	P17342
	P70180
NM_000908; NM_001204375; NM_001204376; NM_024563; NM_001363652;
	NM_001364458; NM_001364460
	NM_001039181; NM_001286395; NM_008728
NP_000899; NP_001191304; NP_001191305; NP_001350581; NP_001351387;
	NP_001351389
	NP_001034270; NP_001273324; NP_032754
	Wikidata
View/Edit Human	View/Edit Mouse

Natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C), also known as NPR3, is an atrial natriuretic peptide receptor. In humans it is encoded by the NPR3 gene.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000113389 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022206 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: NPR3 natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000113389 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022206 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: NPR3 natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)".

[1]

[2]

[3]

[4]

[5]