NUAK1

NUAK1
Identifiers
Aliases	NUAK1, ARK5, NUAK family kinase 1
External IDs	OMIM: 608130; MGI: 1925226; HomoloGene: 8896; GeneCards: NUAK1; OMA:NUAK1 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	106,138,954 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	84,276,461 bp
RNA expression pattern
	Top expressed in
	Brodmann area 23; ; middle temporal gyrus; ; hair follicle; ; Brodmann area 10; ; parietal lobe; ; postcentral gyrus; ; frontal pole; ; Brodmann area 46; ; endothelial cell; ; orbitofrontal cortex;
	Top expressed in
	interventricular septum; ; calvaria; ; stroma of bone marrow; ; pontine nuclei; ; primary motor cortex; ; otic vesicle; ; ganglionic eminence; ; ankle; ; cerebellar vermis; ; soleus muscle;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; p53 binding; metal ion binding; kinase activity; protein binding; ATP binding; protein serine/threonine kinase activity;
Cellular component	cytoplasm; microtubule cytoskeleton; nucleus; nucleoplasm; fibrillar center;
Biological process	intracellular signal transduction; phosphorylation; cellular response to DNA damage stimulus; protein phosphorylation; regulation of cell adhesion; cell adhesion; regulation of cell population proliferation; regulation of cellular senescence; regulation of myosin-light-chain-phosphatase activity; regulation of signal transduction by p53 class mediator;
	Sources:Amigo / QuickGO
Orthologs
	9891
	77976
	ENSG00000074590
	ENSMUSG00000020032
	O60285
	Q641K5
	NM_014840
	NM_001004363
	NP_055655; NP_055655.1
	NP_001004363
	Wikidata
View/Edit Human	View/Edit Mouse

NUAK family SNF1-like kinase 1 also known as AMPK-related protein kinase 5 (ARK5) is an enzyme that in humans is encoded by the NUAK1 gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000074590 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020032 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Suzuki A, Kusakai G, Kishimoto A, Lu J, Ogura T, Lavin MF, Esumi H (Dec 2002). "Identification of a novel protein kinase mediating Akt survival signaling to the ATM protein" (PDF). J Biol Chem. 278 (1): 48–53. doi:10.1074/jbc.M206025200. PMID 12409306. S2CID 23605132.
^ Suzuki A, Kusakai G, Kishimoto A, Lu J, Ogura T, Esumi H (Sep 2003). "ARK5 suppresses the cell death induced by nutrient starvation and death receptors via inhibition of caspase 8 activation, but not by chemotherapeutic agents or UV irradiation". Oncogene. 22 (40): 6177–82. doi:10.1038/sj.onc.1206899. PMID 13679856. S2CID 20975883.
^ "Entrez Gene: NUAK1 NUAK family, SNF1-like kinase, 1".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000074590 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020032 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12409306-5] Suzuki A, Kusakai G, Kishimoto A, Lu J, Ogura T, Lavin MF, Esumi H (Dec 2002). "Identification of a novel protein kinase mediating Akt survival signaling to the ATM protein" (PDF). J Biol Chem. 278 (1): 48–53. doi:10.1074/jbc.M206025200. PMID 12409306. S2CID 23605132.

[pmid13679856-6] Suzuki A, Kusakai G, Kishimoto A, Lu J, Ogura T, Esumi H (Sep 2003). "ARK5 suppresses the cell death induced by nutrient starvation and death receptors via inhibition of caspase 8 activation, but not by chemotherapeutic agents or UV irradiation". Oncogene. 22 (40): 6177–82. doi:10.1038/sj.onc.1206899. PMID 13679856. S2CID 20975883.

[entrez-7] "Entrez Gene: NUAK1 NUAK family, SNF1-like kinase, 1".

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