The tenth season of NYPD Blue premiered on ABC on September 24, 2002, and concluded on May 20, 2003.
| NYPD Blue | |
|---|---|
| Season 10 | |
 Season 10 U.S. DVD Cover | |
| No. of episodes | 22 |
| Release | |
| Original network | ABC |
| Original release | September 24, 2002 – May 20, 2003 |
| Season chronology | |
| Actor | Character | Main cast | Recurring cast |
|---|---|---|---|
| Dennis Franz | Andy Sipowicz | entire season | — |
| Mark-Paul Gosselaar | John Clark Jr. | entire season | — |
| Gordon Clapp | Greg Medavoy | entire season | — |
| Henry Simmons | Baldwin Jones | entire season | — |
| Charlotte Ross | Connie McDowell | entire season | — |
| Garcelle Beauvais | Valerie Haywood | entire season | — |
| Jacqueline Obradors | Rita Ortiz | entire season | — |
| Bill Brochtrup | John Irvin | entire season | — |
| Esai Morales | Tony Rodriguez | entire season | — |
| John F. O'Donohue | Eddie Gibson | — | episode 9 |
| Kim Delaney | Diane Russell | — | episode 21 |