Naltrexone/bupropion

Naltrexone/bupropion
Skeletal structures of bupropion (top) and naltrexone (bottom)
Combination of
NaltrexoneOpioid receptor antagonist
BupropionNorepinephrine-dopamine reuptake inhibitor and nicotinic acetylcholine receptor antagonist
Clinical data
Trade namesContrave, Mysimba
AHFS/Drugs.comMonograph
Routes of
administration		By mouth
ATC code
Legal status
Legal status
Identifiers
CAS Number
PubChem CID
KEGG
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Naltrexone/bupropion, sold under the brand name Contrave among others, is a fixed-dose combination medication for the management of chronic obesity in adults in combination with a reduced-calorie diet and increased physical activity.[4][6] It contains naltrexone, an opioid antagonist, and bupropion, an aminoketone atypical antidepressant.[4] It is taken by mouth.[4] Both medications have individually shown some evidence of effectiveness in weight loss, and the combination has been shown to have some synergistic effects on weight.[7]

In September 2014, a sustained release formulation of the drug was approved for marketing in the United States under the brand name Contrave.[8][9] The combination was subsequently approved in the European Union in the spring of 2015, where it is sold under the name Mysimba.[5][10] It was approved in Canada under the Contrave brand name in 2018.[11]

  1. ^ "FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 October 2023.
  2. ^ "Regulatory Decision Summary — Contrave". Health Canada. 23 October 2014. Archived from the original on 4 December 2020. Retrieved 7 June 2022.
  3. ^ "Drug and medical device highlights 2018: Helping you maintain and improve your health". Health Canada. 14 October 2020. Archived from the original on 17 April 2024. Retrieved 17 April 2024.
  4. ^ a b c d "Contrave Extended-Release- naltrexone hydrochloride and bupropion hydrochloride tablet, extended release". DailyMed. 26 April 2019. Archived from the original on 4 June 2020. Retrieved 5 August 2020.
  5. ^ a b "Mysimba EPAR". European Medicines Agency (EMA). 17 September 2018. Archived from the original on 22 October 2020. Retrieved 5 August 2020. Text was copied from this source which is copyright European Medicines Agency. Reproduction is authorized provided the source is acknowledged.
  6. ^ Plodkowski RA, Nguyen Q, Sundaram U, Nguyen L, Chau DL, St Jeor S (April 2009). "Bupropion and naltrexone: a review of their use individually and in combination for the treatment of obesity". Expert Opinion on Pharmacotherapy. 10 (6): 1069–81. doi:10.1517/14656560902775750. PMID 19364254. S2CID 56625956.
  7. ^ Tek C (2016). "Naltrexone HCI/bupropion HCI for chronic weight management in obese adults: patient selection and perspectives". Patient Preference and Adherence. 10: 751–9. doi:10.2147/PPA.S84778. PMC 4862388. PMID 27217728.
  8. ^ "Drug Approval Package: Contrave (naltrexone hydrochloride/bupropion hydrochloride) Extended-Release Tablets NDA #200063". U.S. Food and Drug Administration (FDA). 12 November 2014. Archived from the original on 4 June 2020. Retrieved 5 August 2020.
  9. ^ Cite error: The named reference fda20140911 was invoked but never defined (see the help page).
  10. ^ Orexigen Therapeutics, Inc. (26 March 2015). "Orexigen's Mysimba Approved in Europe for the Treatment of Obesity". Yahoo! Finance. PR Newswire. Archived from the original on 31 March 2015. Retrieved 28 March 2015.
  11. ^ "Regulatory Decision Summary — Contrave — Health Canada". Health Canada. 13 February 2018. Archived from the original on 4 December 2020. Retrieved 5 September 2021.