Nancy Moffette Lea (1780–1864) was the mother of Margaret Lea Houston and mother-in-law of Sam Houston. She was an integral member of the Houston family, running the household when Margaret was ill or pregnant. She is believed to have helped her son-in-law convert and be baptized in 1854. In appreciation, she donated a bell to the Independence Baptist Church in honor of him. The wife of Temple Lea, she inherited an estate from her family that she managed. She purchased a cotton plantation which was operated by 50 enslaved people.