Naphazoline

Naphazoline

Clinical data
Trade names	Clear Eyes, Cleari, Naphcon-A, Rohto
AHFS/Drugs.com	Monograph
Routes of administration	Ophthalmic drug administration, nasal administration
ATC code	R01AA08 (WHO) S01GA01 (WHO)
Legal status
Legal status	In general: Over-the-counter (OTC)
Identifiers
IUPAC name 2-(naphthalen-1-ylmethyl)-4,5-dihydro-1H-imidazole
CAS Number	835-31-4 N
PubChem CID	4436
IUPHAR/BPS	5509
DrugBank	DB06711 Y
ChemSpider	4283 Y
UNII	H231GF11BV
KEGG	D08253 Y
ChEMBL	ChEMBL761 Y
CompTox Dashboard (EPA)	DTXSID3048449
ECHA InfoCard	100.011.492
Chemical and physical data
Formula	C14H14N2
Molar mass	210.280 g·mol−1
3D model (JSmol)	Interactive image
SMILES N\1=C(\NCC/1)Cc2cccc3c2cccc3
InChI InChI=1S/C14H14N2/c1-2-7-13-11(4-1)5-3-6-12(13)10-14-15-8-9-16-14/h1-7H,8-10H2,(H,15,16) Y Key:CNIIGCLFLJGOGP-UHFFFAOYSA-N Y
NY (what is this?)  (verify)

Naphazoline is a medicine used as a decongestant, and a vasoconstrictor added to eye drops to relieve red eye. It has a rapid action in reducing swelling when applied to mucous membranes. It is a sympathomimetic agent with marked alpha adrenergic activity that acts on alpha-receptors in the arterioles of the conjunctiva to produce constriction, resulting in decreased congestion.

It was patented in 1934 and came into medical use in 1942.^[1]