Nav1.8

SCN10A
Identifiers
Aliases	SCN10A, FEPS2, Nav1.8, PN3, SNS, hPN3, sodium voltage-gated channel alpha subunit 10
External IDs	OMIM: 604427; MGI: 108029; HomoloGene: 21300; GeneCards: SCN10A; OMA:SCN10A - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	38,816,286 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	119,548,388 bp
RNA expression pattern
	Top expressed in
	pancreatic ductal cell; ; tibialis anterior muscle; ; mucosa of ileum; ; lower lobe of lung; ; deltoid muscle; ; spinal ganglia; ; skin of hip; ; trigeminal ganglion; ; skin of thigh; ; gonad;
	Top expressed in
	spinal ganglia; ; trigeminal ganglion; ; primary oocyte; ; embryonic cell; ; zygote; ; secondary oocyte; ; glossopharyngeal ganglion; ; spinal cord; ; neural tube; ; heart;
	More reference expression data
	n/a
Gene ontology
Molecular function	voltage-gated sodium channel activity; ion channel activity; transmembrane transporter binding; sodium channel activity; voltage-gated ion channel activity;
Cellular component	integral component of membrane; voltage-gated sodium channel complex; membrane; clathrin complex; extracellular exosome; plasma membrane; axon; glutamatergic synapse; integral component of presynaptic membrane;
Biological process	bundle of His cell action potential; sodium ion transmembrane transport; transmembrane transport; neuronal action potential; regulation of heart rate; regulation of atrial cardiac muscle cell membrane depolarization; membrane depolarization during action potential; sensory perception of pain; regulation of ion transmembrane transport; ion transport; regulation of cardiac muscle contraction; AV node cell action potential; sodium ion transport; odontogenesis of dentin-containing tooth; sensory perception; regulation of postsynaptic membrane potential; transport;
	Sources:Amigo / QuickGO
Orthologs
	6336
	20264
	ENSG00000185313
	ENSMUSG00000034533
	Q9Y5Y9
	Q6QIY3
	NM_001293306; NM_001293307; NM_006514
	NM_001205321; NM_009134
	NP_001280235; NP_001280236; NP_006505
	NP_001192250; NP_033160
	Wikidata
View/Edit Human	View/Edit Mouse

Na_v1.8 is a sodium ion channel subtype that in humans is encoded by the SCN10A gene.^[5]^[6]^[7]^[8]

Na_v1.8-containing channels are tetrodotoxin (TTX)-resistant voltage-gated channels. Na_v1.8 is expressed specifically in the dorsal root ganglion (DRG), in unmyelinated, small-diameter sensory neurons called C-fibres, and is involved in nociception.^[9]^[10] C-fibres can be activated by noxious thermal or mechanical stimuli and thus can carry pain messages.

The specific location of Na_v1.8 in sensory neurons of the DRG may make it a key therapeutic target for the development of new analgesics^[11] and the treatment of chronic pain.^[12]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000185313 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000034533 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: sodium channel".
^ Rabert DK, Koch BD, Ilnicka M, Obernolte RA, Naylor SL, Herman RC, Eglen RM, Hunter JC, Sangameswaran L (November 1998). "A tetrodotoxin-resistant voltage-gated sodium channel from human dorsal root ganglia, hPN3/SCN10A". Pain. 78 (2): 107–14. doi:10.1016/S0304-3959(98)00120-1. PMID 9839820. S2CID 45480324.
^ Plummer NW, Meisler MH (April 1999). "Evolution and diversity of mammalian sodium channel genes". Genomics. 57 (2): 323–31. doi:10.1006/geno.1998.5735. PMID 10198179.
^ Catterall WA, Goldin AL, Waxman SG (December 2005). "International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels". Pharmacological Reviews. 57 (4): 397–409. doi:10.1124/pr.57.4.4. PMID 16382098. S2CID 7332624.
^ Akopian AN, Souslova V, England S, Okuse K, Ogata N, Ure J, Smith A, Kerr BJ, McMahon SB, Boyce S, Hill R, Stanfa LC, Dickenson AH, Wood JN (June 1999). "The tetrodotoxin-resistant sodium channel SNS has a specialized function in pain pathways". Nature Neuroscience. 2 (6): 541–8. doi:10.1038/9195. PMID 10448219. S2CID 17487906.
^ Akopian AN, Sivilotti L, Wood JN (January 1996). "A tetrodotoxin-resistant voltage-gated sodium channel expressed by sensory neurons". Nature. 379 (6562): 257–62. Bibcode:1996Natur.379..257A. doi:10.1038/379257a0. PMID 8538791. S2CID 4360775.
^ Cummins TR, Sheets PL, Waxman SG (October 2007). "The roles of sodium channels in nociception: Implications for mechanisms of pain". Pain. 131 (3): 243–57. doi:10.1016/j.pain.2007.07.026. PMC 2055547. PMID 17766042.
^ Swanwick RS, Pristerá A, Okuse K (December 2010). "The trafficking of Na(V)1.8". Neuroscience Letters. 486 (2): 78–83. doi:10.1016/j.neulet.2010.08.074. PMC 2977848. PMID 20816723.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000185313 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000034533 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: sodium channel".

[pmid9839820-6] Rabert DK, Koch BD, Ilnicka M, Obernolte RA, Naylor SL, Herman RC, Eglen RM, Hunter JC, Sangameswaran L (November 1998). "A tetrodotoxin-resistant voltage-gated sodium channel from human dorsal root ganglia, hPN3/SCN10A". Pain. 78 (2): 107–14. doi:10.1016/S0304-3959(98)00120-1. PMID 9839820. S2CID 45480324.

[pmid10198179-7] Plummer NW, Meisler MH (April 1999). "Evolution and diversity of mammalian sodium channel genes". Genomics. 57 (2): 323–31. doi:10.1006/geno.1998.5735. PMID 10198179.

[pmid16382098-8] Catterall WA, Goldin AL, Waxman SG (December 2005). "International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels". Pharmacological Reviews. 57 (4): 397–409. doi:10.1124/pr.57.4.4. PMID 16382098. S2CID 7332624.

[Akopian1999-9] Akopian AN, Souslova V, England S, Okuse K, Ogata N, Ure J, Smith A, Kerr BJ, McMahon SB, Boyce S, Hill R, Stanfa LC, Dickenson AH, Wood JN (June 1999). "The tetrodotoxin-resistant sodium channel SNS has a specialized function in pain pathways". Nature Neuroscience. 2 (6): 541–8. doi:10.1038/9195. PMID 10448219. S2CID 17487906.

[Akopian1996-10] Akopian AN, Sivilotti L, Wood JN (January 1996). "A tetrodotoxin-resistant voltage-gated sodium channel expressed by sensory neurons". Nature. 379 (6562): 257–62. Bibcode:1996Natur.379..257A. doi:10.1038/379257a0. PMID 8538791. S2CID 4360775.

[pmid17766042-11] Cummins TR, Sheets PL, Waxman SG (October 2007). "The roles of sodium channels in nociception: Implications for mechanisms of pain". Pain. 131 (3): 243–57. doi:10.1016/j.pain.2007.07.026. PMC 2055547. PMID 17766042.

[Swanwick2010-12] Swanwick RS, Pristerá A, Okuse K (December 2010). "The trafficking of Na(V)1.8". Neuroscience Letters. 486 (2): 78–83. doi:10.1016/j.neulet.2010.08.074. PMC 2977848. PMID 20816723.

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