Nef (protein)

Negative factor, (F-Protein) or Nef
NMR structure of the NEF protein based on the PDB: 2NEF​ coordinates.
Identifiers
SymbolF-protein
PfamPF00469
InterProIPR001558
SCOP21avv / SCOPe / SUPFAM
OPM superfamily269
OPM protein2nef
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary

Nef (Negative Regulatory Factor) is a small 27-35 kDa myristoylated protein encoded by primate lentiviruses. These include Human Immunodeficiency Viruses (HIV-1 and HIV-2) and Simian Immunodeficiency Virus (SIV). Nef localizes primarily to the cytoplasm but also partially to the Plasma membrane (PM) and is one of many pathogen-expressed proteins, known as virulence factors, which function to manipulate the host's cellular machinery and thus allow infection, survival or replication of the pathogen.[1] Nef stands for "Negative Factor" and although it is often considered indispensable for HIV-1 replication, in infected hosts the viral protein markedly elevates viral titers.[2]

  1. ^ Das SR, Jameel S (April 2005). "Biology of the HIV Nef protein" (PDF). Indian J. Med. Res. 121 (4): 315–32. PMID 15817946. Archived from the original (PDF) on 2017-08-10. Retrieved 2008-08-07.
  2. ^ Marcey D, Somple M, Silva N (2007-01-01). "HIV-1 Nef Protein". The Online Macromolecular Museum Exhibits. California Lutheran University. Retrieved 2008-08-06.