In molecular biology, the NELF (negative elongation factor) is a four-subunit protein complex (NELF-A, NELF-B, NELF-C/NELF-D, and NELF-E) that negatively impacts transcription by RNA polymerase II (Pol II) by pausing about 20-60 nucleotides downstream from the transcription start site (TSS).[1][2]
- ^ Adelman K, Lis JT (October 2012). "Promoter-proximal pausing of RNA polymerase II: emerging roles in metazoans". Nature Reviews. Genetics. 13 (10): 720–31. doi:10.1038/nrg3293. PMC 3552498. PMID 22986266.
- ^ Aoi Y, Smith ER, Shah AP, Rendleman EJ, Marshall SA, Woodfin AR, et al. (April 2020). "NELF Regulates a Promoter-Proximal Step Distinct from RNA Pol II Pause-Release". Molecular Cell. 78 (2): 261–274.e5. doi:10.1016/j.molcel.2020.02.014. PMC 7402197. PMID 32155413.