Negri body

Histopathology of Negri bodies in rabies encephalitis.
Micrograph with numerous rabies virions (small dark-grey rod-like particles) and Negri bodies, larger pathognomonic cellular inclusion bodies of rabies infection.

Negri bodies are eosinophilic, sharply outlined, pathognomonic inclusion bodies (2–10 μm in diameter) found in the cytoplasm of certain nerve cells containing the virus of rabies, especially in pyramidal cells[1] within Ammon's horn of the hippocampus. They are also often found in the Purkinje cells[1] of the cerebellar cortex from postmortem brain samples of rabies victims. They consist of ribonuclear proteins produced by the virus.[2]

They are named for Adelchi Negri.[3]

  1. ^ a b Sketchy Group, LLC. "2.3 Rhabdovirus". www.sketchymedical.com. Archived from the original on 2017-04-13. Retrieved 2017-04-12.
  2. ^ Lahaye, Xavier; Vidy, Aurore; Pomier, Carole; Obiang, Linda; Harper, Francis; Gaudin, Yves; Blondel, Danielle (15 August 2009). "Functional Characterization of Negri Bodies (NBs) in Rabies Virus-Infected Cells: Evidence that NBs Are Sites of Viral Transcription and Replication". Journal of Virology. 83 (16): 7948–7958. doi:10.1128/JVI.00554-09. ISSN 0022-538X. PMC 2715764. PMID 19494013.
  3. ^ synd/2491 at Who Named It?