Nemonapride

Nemonapride
Clinical data
Trade namesEmilace (JP, CN)
Other namesEmonapride; Emirace; YM 09151-2; YM09151-2; YM 09151; YM09151
AHFS/Drugs.comInternational Drug Names
Routes of
administration		Oral[1][2]
Drug classDopamine D2, D3, and D4 receptor antagonist; Serotonin 5-HT1A receptor partial agonist; Antipsychotic
ATC code
  • None
Legal status
Legal status
  • Rx-only (JP)
Pharmacokinetic data
MetabolismPrimarily CYP3A4[2]
Elimination half-life2.3–4.5 hours[2]
Identifiers
  • N-(1-benzyl-2-methylpyrrolidin-3-yl)-5-chloro-2-methoxy-4-(methylamino)benzamide
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
PDB ligand
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC21H26ClN3O2
Molar mass387.91 g·mol−1
3D model (JSmol)
  • CC1C(CCN1CC2=CC=CC=C2)NC(=O)C3=CC(=C(C=C3OC)NC)Cl
  • InChI=1S/C21H26ClN3O2/c1-14-18(9-10-25(14)13-15-7-5-4-6-8-15)24-21(26)16-11-17(22)19(23-2)12-20(16)27-3/h4-8,11-12,14,18,23H,9-10,13H2,1-3H3,(H,24,26)
  • Key:KRVOJOCLBAAKSJ-UHFFFAOYSA-N
  (verify)

Nemonapride, also previously known as emonapride and sold under the brand name Emilace, is an atypical antipsychotic which is used in the treatment of schizophrenia.[1][2][3] It is taken by mouth.[1][2]

Side effects of nemonapride include akathisia, dystonia, hypokinesia, tremor, hypersalivation, and hyperprolactinemia, among others.[1][2] The drug acts as a dopamine D2, D3, and D4 receptor antagonist.[1] To a lesser extent, it is also a serotonin 5-HT1A receptor partial agonist.[4] Structurally, nemonapride is a benzamide derivative and is related to sulpiride and other benzamides.[1]

Nemonapride was introduced for medical use in either 1991[5] or 1997.[1][6] It was developed and marketed by Yamanouchi Pharmaceuticals.[6][7] The drug is approved only in Japan and China.[8]

  1. ^ a b c d e f g Bishara D, Taylor D (2008). "Upcoming agents for the treatment of schizophrenia: mechanism of action, efficacy and tolerability". Drugs. 68 (16): 2269–2292. doi:10.2165/0003495-200868160-00002. PMID 18973393.
  2. ^ a b c d e f "医療用医薬品 : エミレース (エミレース錠3mg 他)". KEGG (in Japanese). 18 September 2024. Retrieved 24 October 2024.
  3. ^ "Nemonapride". AdisInsight. 6 June 2007. Retrieved 24 October 2024.
  4. ^ Kusumi I, Boku S, Takahashi Y (May 2015). "Psychopharmacology of atypical antipsychotic drugs: From the receptor binding profile to neuroprotection and neurogenesis". Psychiatry and Clinical Neurosciences. 69 (5). Wiley: 243–258. doi:10.1111/pcn.12242. PMID 25296946. S2CID 23102204.
  5. ^ Cite error: The named reference PMDA was invoked but never defined (see the help page).
  6. ^ a b Burke A, Marques C, Turner N, Hermann G (2018). Active Pharmaceutical Ingredients in Synthesis: Catalytic Processes in Research and Development. Wiley. p. 380. ISBN 978-3-527-34241-9. Retrieved 24 October 2024.
  7. ^ Cite error: The named reference IndexNominum2004 was invoked but never defined (see the help page).
  8. ^ "Nemonapride". Drugs.com. Archived from the original on 2016-03-03.