Neomura (from Ancient Greek neo- "new", and Latin -murus "wall") is a proposed clade of biological life composed of the two domains Archaea and Eukaryota, coined by Thomas Cavalier-Smith in 2002.[1] Its name reflects the hypothesis that both archaea and eukaryotes evolved out of the domain Bacteria, and one of the major changes was the replacement of the bacterial peptidoglycan cell walls with other glycoproteins.
As of August 2017[update], the neomuran hypothesis is not accepted by most scientific workers; molecular phylogenies suggest that eukaryotes are most closely related to one group of archaeans and evolved from them, rather than forming a clade with all archaeans, and that archaea and bacteria are sister groups both descended from LUCA.