The Nepisiguit River is a major river in northern New Brunswick, Canada, which enters the sea at the city of Bathurst, into the Nepisiguit Bay, part of the Bay of Chaleur.
Appears in Jesuit Relations (1643) as Nepegiguit, a corruption through the French of the Micmac Win-peg-ij-oo-ik, "the river that dashes roughly along", a reference to the torrential character of the river.[1]