Nerve growth factor

NGF
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4ZBN, 1SG1, 1WWW, 2IFG, 4EDW, 4EDX
Identifiers
Aliases	NGF, Beta-HSAN5, NGFB, nerve growth factor
External IDs	OMIM: 162030; MGI: 97321; HomoloGene: 1876; GeneCards: NGF; OMA:NGF - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p13.2 Start 115,285,904 bp[1] End 115,338,770 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3 F2.2|3 45.25 cM Start 102,377,235 bp[2] End 102,428,329 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cartilage tissue left uterine tube right auricle right ovary apex of heart ascending aorta left ovary tibial arteries left ventricle Descending thoracic aorta Top expressed in submandibular gland right ventricle embryo genital tubercle endothelial cell of lymphatic vessel dentate gyrus of hippocampal formation granule cell embryo skin of lower limb right kidney middle ear More reference expression data BioGPS More reference expression data
Gene ontology Molecular function peptidase inhibitor activity enzyme inhibitor activity protein binding metalloendopeptidase inhibitor activity nerve growth factor receptor binding growth factor activity signaling receptor binding Cellular component endosome Golgi lumen extracellular region cytoplasmic vesicle extracellular space cytosol synaptic vesicle axon dendrite Biological process negative regulation of neuron apoptotic process regulation of neuron differentiation neuron projection morphogenesis negative regulation of peptidase activity neurotrophin TRK receptor signaling pathway cell-cell signaling negative regulation of apoptotic process regulation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of axonogenesis positive regulation of gene expression positive regulation of apoptotic process nerve growth factor processing extrinsic apoptotic signaling pathway via death domain receptors phosphatidylinositol-mediated signaling negative regulation of cysteine-type endopeptidase activity involved in apoptotic process microtubule-based movement activation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of Ras protein signal transduction transmembrane receptor protein tyrosine kinase signaling pathway peripheral nervous system development memory negative regulation of cell population proliferation regulation of signaling receptor activity nerve development nerve growth factor signaling pathway positive regulation of DNA binding positive regulation of neuron differentiation positive regulation of collateral sprouting modulation of chemical synaptic transmission Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4803 18049 Ensembl ENSG00000134259 ENSMUSG00000027859 UniProt P01138 P01139 RefSeq (mRNA) NM_002506 NM_001112698 NM_013609 RefSeq (protein) NP_002497 NP_001106168 NP_038637 Location (UCSC) Chr 1: 115.29 – 115.34 Mb Chr 3: 102.38 – 102.43 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Nerve growth factor (NGF) is a neurotrophic factor and neuropeptide primarily involved in the regulation of growth, maintenance, proliferation, and survival of certain target neurons. It is perhaps the prototypical growth factor, in that it was one of the first to be described. Since it was first isolated by Nobel Laureates Rita Levi-Montalcini and Stanley Cohen in 1956, numerous biological processes involving NGF have been identified, two of them being the survival of pancreatic beta cells and the regulation of the immune system.