| Darejan of Kartli | |
|---|---|
| Queen consort of Kartli | |
| Tenure | 1556–1569 1578–1599 |
| Died | 1612 |
| Spouse | Simon I of Kartli |
| Issue | George X of Kartli |
| Dynasty | Bagrationi dynasty |
| Father | Levan of Kakheti |
| Religion | Georgian Orthodox Church |
| Khelrtva | .svg) |
Nestan-Darejan (Georgian: ნესტან-დარეჯანი; fl. 1556–1612) was queen consort of Kartli, a kingdom in eastern Georgia, as the wife of King Simon I, whom she married in 1559. Nestan-Darejan was a daughter of King Levan of Kakheti and a half-sister of Levan's successor to the throne of Kingdom of Kakheti, Alexander II. Her husband spent nearly five decades fighting the Safavid Iranian and Ottoman encroachments on his kingdom, twice losing his throne and personal freedom. Nestan-Darejan suffered further, being humiliated by his half-brother, the king of Kakheti, who capitalized on Simon's difficulties to attack and loot Kartli. After Simon had been sent a prisoner to Iran in 1569, Nestan-Darejan's estates had been pillaged by Prince Bardzim Amilakhori, Alexander's father-in-law; and in 1580, following Simon's return to Kartli and his defeat by Alexander at Dighomi, the latter carried off after the battle his half-sister's drawers on the point of a lance. Nestan-Darejan outlived her husband and died sometime after 1612, having mothered six children, including Simon's successor to the throne of Kartli, George X.