Nestor is a residential neighborhood in the southern section of San Diego, California, part of the Otay Mesa-Nestor community planning area. It neighbors Palm City and Otay Mesa West to the east, Egger Highlands to the north, San Ysidro to the southeast and the Tijuana River Valley to the south. Major thoroughfares include Coronado Avenue, Saturn Boulevard, Hollister Street, and Tocayo Avenue.