Netrin 1

NTN1
Available structures
PDB	Ortholog search: O95631 PDBe O95631 RCSB
List of PDB id codes
	4URT
Identifiers
Aliases	NTN1, NTN1L, netrin 1, MRMV4
External IDs	OMIM: 601614; MGI: 105088; HomoloGene: 21008; GeneCards: NTN1; OMA:NTN1 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	9,244,000 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	68,291,649 bp
RNA expression pattern
	Top expressed in
	gastric mucosa; ; right auricle; ; Descending thoracic aorta; ; ascending aorta; ; popliteal artery; ; tibial arteries; ; olfactory zone of nasal mucosa; ; apex of heart; ; parotid gland; ; mucosa of esophagus;
	Top expressed in
	Cerebral white matter; ; tunica media of zone of aorta; ; ankle joint; ; ankle; ; dermis; ; ascending aorta; ; vas deferens; ; aortic valve; ; atrium; ; myocardium of ventricle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding;
Cellular component	extracellular region; cytoplasm; basement membrane;
Biological process	mammary gland duct morphogenesis; positive regulation of cell motility; axon guidance; substrate-dependent cell migration, cell extension; Cdc42 protein signal transduction; positive regulation of axon extension; inner ear morphogenesis; negative regulation of axon extension; apoptotic process; mammary gland development; positive regulation of cell population proliferation; regulation of cell migration; Ras protein signal transduction; anterior/posterior axon guidance; neuron migration; axonogenesis; nuclear migration; cell-cell adhesion; negative regulation of netrin-activated signaling pathway; regulation of synapse assembly; chemorepulsion of axon; motor neuron axon guidance; animal organ morphogenesis; tissue development; dendrite development;
	Sources:Amigo / QuickGO
Orthologs
	9423
	18208
	ENSG00000065320
	ENSMUSG00000020902
	H7BZF4; O95631
	O09118
	NM_004822
	NM_008744
	NP_004813
	NP_032770
	Wikidata
View/Edit Human	View/Edit Mouse

Netrin-1 is a protein that in humans is encoded by the NTN1 gene.^[5]^[6]

Netrin is included in a family of laminin-related secreted proteins. The function of this gene has not yet been defined; however, netrin is thought to be involved in axon guidance and cell migration during development. Mutations and loss of expression of netrin suggest that variation in netrin may be involved in cancer development.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000065320 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020902 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Meyerhardt JA, Caca K, Eckstrand BC, Hu G, Lengauer C, Banavali S, Look AT, Fearon ER (January 1999). "Netrin-1: interaction with deleted in colorectal cancer (DCC) and alterations in brain tumors and neuroblastomas". Cell Growth Differ. 10 (1): 35–42. PMID 9950216.
^ ^a ^b "Entrez Gene: NTN1 netrin 1".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000065320 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020902 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9950216-5] Meyerhardt JA, Caca K, Eckstrand BC, Hu G, Lengauer C, Banavali S, Look AT, Fearon ER (January 1999). "Netrin-1: interaction with deleted in colorectal cancer (DCC) and alterations in brain tumors and neuroblastomas". Cell Growth Differ. 10 (1): 35–42. PMID 9950216.

[entrez-6] "Entrez Gene: NTN1 netrin 1".

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