Neural cell adhesion molecule

NCAM1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesNCAM1, CD56, MSK39, NCAM, neural cell adhesion molecule 1
External IDsOMIM: 116930; MGI: 97281; HomoloGene: 40754; GeneCards: NCAM1; OMA:NCAM1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001081445
NM_001113204
NM_010875
NM_001311065

RefSeq (protein)

NP_000606
NP_001070150
NP_001229536
NP_001229537
NP_851996

NP_001074914
NP_001106675
NP_001297994
NP_035005
NP_001391651

Location (UCSC)Chr 11: 112.96 – 113.28 MbChr 9: 49.41 – 49.71 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Neural cell adhesion molecule (NCAM), also called CD56, is a homophilic binding glycoprotein expressed on the surface of neurons, glia and skeletal muscle. Although CD56 is often considered a marker of neural lineage commitment due to its discovery site, CD56 expression is also found in, among others, the hematopoietic system. Here, the expression of CD56 is mostly associated with, but not limited to, natural killer cells. CD56 has been detected on other lymphoid cells, including gamma delta (γδ) Τ cells and activated CD8+ T cells, as well as on dendritic cells.[5] NCAM has been implicated as having a role in cell–cell adhesion,[6] neurite outgrowth, synaptic plasticity, and learning and memory.

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000149294Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000039542Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Van Acker HH, Capsomidis A, Smits EL, Van Tendeloo VF (2017). "CD56 in the Immune System: More Than a Marker for Cytotoxicity?". Frontiers in Immunology. 8: 892. doi:10.3389/fimmu.2017.00892. PMC 5522883. PMID 28791027.
  6. ^ Pathology Outlines