| Neuregulin family | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
 Structure of the epidermal growth factor-like domain of heregulin-alpha, a ligand for p180erbB-4.[1] | |||||||||||
| Identifiers | |||||||||||
| Symbol | Neuregulin | ||||||||||
| Pfam | PF02158 | ||||||||||
| InterPro | IPR002154 | ||||||||||
| SCOP2 | 1hrf / SCOPe / SUPFAM | ||||||||||
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Neuregulins are a family of four structurally related proteins that are part of the EGF family of proteins. These proteins have been shown to have diverse functions in the development of the nervous system and play multiple essential roles in vertebrate embryogenesis including: cardiac development, Schwann cell and oligodendrocyte differentiation, some aspects of neuronal development, as well as the formation of neuromuscular synapses.[2][3]
Included in the family are heregulin; neu differentiation factor; acetylcholine receptor synthesis stimulator; glial growth factor; and sensory and motor-neuron derived factor.[4] Multiple family members are generated by alternate splicing or by use of several cell type-specific transcription initiation sites. In general, they bind to and activate the erbB family of receptor tyrosine kinases (erbB2 (HER2), erbB3 (HER3), and erbB4 (HER4)), functioning both as heterodimers and homodimers.
- ^ Nagata K, Kohda D, Hatanaka H, et al. (August 1994). "Solution structure of the epidermal growth factor-like domain of heregulin-alpha, a ligand for p180erbB-4". EMBO J. 13 (15): 3517–23. doi:10.1002/j.1460-2075.1994.tb06658.x. PMC 395255. PMID 8062828.
- ^ Vartanian T, Fischbach G, Miller R (1999). "Failure of spinal cord oligodendrocyte development in mice lacking neuregulin". Proc. Natl. Acad. Sci. U.S.A. 96 (2): 731–5. Bibcode:1999PNAS...96..731V. doi:10.1073/pnas.96.2.731. PMC 15205. PMID 9892702.
- ^ Yarden Y, Burden S (1997). "Neuregulins and their receptors: a versatile signaling module in organogenesis and oncogenesis". Neuron. 18 (6): 847–55. doi:10.1016/S0896-6273(00)80324-4. PMID 9208852.
- ^ Schroering A, Carey DJ (1998). "Sensory and motor neuron-derived factor is a transmembrane heregulin that is expressed on the plasma membrane with the active domain exposed to the extracellular environment". J. Biol. Chem. 273 (46): 30643–50. doi:10.1074/jbc.273.46.30643. PMID 9804837.