Neuregulin 1

NRG1
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 1HAE, 1HAF, 1HRE, 1HRF, 3U7U
Identifiers
Aliases	NRG1, ARIA, GGF, GGF2, HGL, HRG, HRG1, HRGA, MST131, MSTP131, NDF, NRG1-IT2, SMDF, neuregulin 1
External IDs	OMIM: 142445; HomoloGene: 8509; GeneCards: NRG1; OMA:NRG1 - orthologs
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8p12 Start 31,639,222 bp[1] End 32,855,666 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone ganglionic eminence oocyte secondary oocyte monocyte granulocyte stromal cell of endometrium spinal ganglia gonad endothelial cell n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transmembrane receptor protein tyrosine kinase activator activity protein tyrosine kinase activator activity signaling receptor binding cytokine activity transcription coregulator activity growth factor activity protein binding chemorepellent activity receptor tyrosine kinase binding ErbB-2 class receptor binding protein tyrosine kinase activity phosphatidylinositol-4,5-bisphosphate 3-kinase activity ErbB-3 class receptor binding integrin binding Cellular component cytoplasm membrane synapse extracellular region nucleus apical plasma membrane integral component of membrane neuromuscular junction plasma membrane axon cell body integral component of plasma membrane dendrite axolemma external side of plasma membrane nucleoplasm extracellular space glutamatergic synapse GABA-ergic synapse Biological process cardiac conduction system development embryo development positive regulation of Ras protein signal transduction muscle organ development oligodendrocyte differentiation positive regulation of dendritic spine development mammary gland development axon ensheathment cell communication chemorepulsion involved in interneuron migration from the subpallium to the cortex positive regulation of cardiac muscle cell proliferation positive regulation of protein localization to cell surface positive regulation of striated muscle cell differentiation cell population proliferation locomotory behavior negative regulation of protein catabolic process transmembrane receptor protein tyrosine kinase signaling pathway cardiac muscle cell differentiation endocardial cell differentiation heart development positive regulation of cell growth cardiac muscle cell myoblast differentiation positive regulation of peptidyl-tyrosine phosphorylation synapse assembly positive regulation of cardiac muscle cell differentiation positive regulation of axon extension peripheral nervous system development startle response regulation of protein heterodimerization activity wound healing glial cell differentiation nervous system development ventricular trabecula myocardium morphogenesis glial cell fate commitment negative regulation of cardiac muscle cell apoptotic process negative regulation of transcription, DNA-templated regulation of protein homodimerization activity neurotransmitter receptor metabolic process positive regulation of protein kinase activity negative regulation of neuron migration neurogenesis neural crest cell development MAPK cascade positive regulation of calcineurin-NFAT signaling cascade positive regulation of myelination brain development negative regulation of secretion cell morphogenesis regulation of cell differentiation ventricular cardiac muscle cell differentiation positive regulation of phosphatidylinositol 3-kinase signaling neuron fate commitment negative regulation of extrinsic apoptotic signaling pathway in absence of ligand cell migration positive regulation of cell adhesion positive regulation of transcription by RNA polymerase II phosphatidylinositol phosphate biosynthetic process positive regulation of gene expression positive regulation of cell population proliferation ERBB signaling pathway activation of protein kinase B activity regulation of cell motility peptidyl-tyrosine phosphorylation positive regulation of protein tyrosine kinase activity ERBB2 signaling pathway activation of transmembrane receptor protein tyrosine kinase activity cardiac muscle tissue development ERBB3 signaling pathway regulation of signaling receptor activity positive regulation of protein kinase B signaling ERBB4 signaling pathway positive regulation of peptidyl-tyrosine autophosphorylation myelination in peripheral nervous system intracellular signal transduction postsynapse to nucleus signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3084 n/a Ensembl ENSG00000157168 n/a UniProt Q02297 Q7RTW3 n/a RefSeq (mRNA) NM_001159995 NM_001159996 NM_001159999 NM_001160001 NM_001160002 NM_001160004 NM_001160005 NM_001160007 NM_001160008 NM_004495 NM_013956 NM_013957 NM_013958 NM_013959 NM_013960 NM_013962 NM_013964 NM_001322197 NM_001322201 NM_001322202 NM_001322205 NM_001322206 NM_001322207 n/a RefSeq (protein) NP_001153467 NP_001153468 NP_001153471 NP_001153473 NP_001153474 NP_001153476 NP_001153477 NP_001153479 NP_001153480 NP_001309126 NP_001309130 NP_001309131 NP_001309134 NP_001309135 NP_001309136 NP_004486 NP_039250 NP_039251 NP_039252 NP_039253 NP_039254 NP_039256 NP_039258 NP_039251.2 NP_001153471.1 NP_001309130.1 n/a Location (UCSC) Chr 8: 31.64 – 32.86 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Neuregulin 1, or NRG1, is a gene of the epidermal growth factor family that in humans is encoded by the NRG1 gene.^[3][4] NRG1 is one of four proteins in the neuregulin family that act on the EGFR family of receptors. Neuregulin 1 is produced in numerous isoforms by alternative splicing, which allows it to perform a wide variety of functions. It is essential for the normal development of the nervous system and the heart.^[5][6]