Neuregulin 2

NRG2
Identifiers
Aliases	NRG2, DON1, HRG2, NTAK, neuregulin 2
External IDs	OMIM: 603818; MGI: 1098246; HomoloGene: 75024; GeneCards: NRG2; OMA:NRG2 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	140,043,299 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	36,330,433 bp
RNA expression pattern
	Top expressed in
	buccal mucosa cell; ; paraflocculus of cerebellum; ; frontal pole; ; middle frontal gyrus; ; Brodmann area 10; ; cerebellar vermis; ; right hemisphere of cerebellum; ; testicle; ; gastrocnemius muscle; ; left ovary;
	Top expressed in
	cerebellar cortex; ; neural layer of retina; ; superior frontal gyrus; ; dentate gyrus of hippocampal formation granule cell; ; granulocyte; ; primary visual cortex; ; lip; ; endocardium of ventricle; ; surface ectoderm; ; morula;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	growth factor activity; signaling receptor binding; protein tyrosine kinase activity; phosphatidylinositol-4,5-bisphosphate 3-kinase activity;
Cellular component	integral component of membrane; membrane; plasma membrane; extracellular region; intracellular anatomical structure; extracellular space;
Biological process	MAPK cascade; signal transduction; regulation of cell motility; phosphatidylinositol phosphate biosynthetic process; peptidyl-tyrosine phosphorylation; ERBB2 signaling pathway; intracellular signal transduction; animal organ development; regulation of signaling receptor activity; positive regulation of protein kinase B signaling; nervous system development;
	Sources:Amigo / QuickGO
Orthologs
	9542
	100042150
	ENSG00000158458
	ENSMUSG00000060275
	O14511
	P56974
NM_001184935; NM_004883; NM_013981; NM_013982; NM_013983;
	NM_013984; NM_013985
	NM_001167891; NM_001382420
	NP_001171864; NP_004874; NP_053584; NP_053585; NP_053586
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Neuregulin 2, also known as NRG2, is a protein which in humans is encoded by the NRG2 gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000158458 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000060275 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: NRG2 neuregulin 2".
^ Chang H, Riese DJ, Gilbert W, Stern DF, McMahan UJ (May 1997). "Ligands for ErbB-family receptors encoded by a neuregulin-like gene". Nature. 387 (6632): 509–12. Bibcode:1997Natur.387R.509C. doi:10.1038/387509a0. PMID 9168114. S2CID 4359654.
^ Carraway KL, Weber JL, Unger MJ, Ledesma J, Yu N, Gassmann M, Lai C (May 1997). "Neuregulin-2, a new ligand of ErbB3/ErbB4-receptor tyrosine kinases". Nature. 387 (6632): 512–6. Bibcode:1997Natur.387R.512C. doi:10.1038/387512a0. PMID 9168115. S2CID 4310136.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000158458 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000060275 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: NRG2 neuregulin 2".

[pmid9168114-6] Chang H, Riese DJ, Gilbert W, Stern DF, McMahan UJ (May 1997). "Ligands for ErbB-family receptors encoded by a neuregulin-like gene". Nature. 387 (6632): 509–12. Bibcode:1997Natur.387R.509C. doi:10.1038/387509a0. PMID 9168114. S2CID 4359654.

[pmid9168115-7] Carraway KL, Weber JL, Unger MJ, Ledesma J, Yu N, Gassmann M, Lai C (May 1997). "Neuregulin-2, a new ligand of ErbB3/ErbB4-receptor tyrosine kinases". Nature. 387 (6632): 512–6. Bibcode:1997Natur.387R.512C. doi:10.1038/387512a0. PMID 9168115. S2CID 4310136.

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