Neurokinin B

Neurokinin B
Identifiers
3D model (JSmol)
ChemSpider
MeSH Neurokinin+B
  • InChI=1S/C55H79N13O14S2/c1-30(2)21-38(50(77)62-36(47(57)74)17-19-83-5)61-43(69)28-59-55(82)46(31(3)4)68-54(81)40(23-33-15-11-8-12-16-33)65-51(78)39(22-32-13-9-7-10-14-32)64-53(80)42(26-45(72)73)67-52(79)41(24-34-27-58-29-60-34)66-49(76)37(18-20-84-6)63-48(75)35(56)25-44(70)71/h7-16,27,29-31,35-42,46H,17-26,28,56H2,1-6H3,(H2,57,74)(H,58,60)(H,59,82)(H,61,69)(H,62,77)(H,63,75)(H,64,80)(H,65,78)(H,66,76)(H,67,79)(H,68,81)(H,70,71)(H,72,73)/t35-,36-,37-,38-,39-,40-,41-,42-,46-/m0/s1 ☒N
    Key: NHXYSAFTNPANFK-HDMCBQFHSA-N ☒N
  • InChI=1/C55H79N13O14S2/c1-30(2)21-38(50(77)62-36(47(57)74)17-19-83-5)61-43(69)28-59-55(82)46(31(3)4)68-54(81)40(23-33-15-11-8-12-16-33)65-51(78)39(22-32-13-9-7-10-14-32)64-53(80)42(26-45(72)73)67-52(79)41(24-34-27-58-29-60-34)66-49(76)37(18-20-84-6)63-48(75)35(56)25-44(70)71/h7-16,27,29-31,35-42,46H,17-26,28,56H2,1-6H3,(H2,57,74)(H,58,60)(H,59,82)(H,61,69)(H,62,77)(H,63,75)(H,64,80)(H,65,78)(H,66,76)(H,67,79)(H,68,81)(H,70,71)(H,72,73)/t35-,36-,37-,38-,39-,40-,41-,42-,46-/m0/s1
    Key: NHXYSAFTNPANFK-HDMCBQFHBC
  • CC(C)C[C@@H](C(=O)N[C@@H](CCSC)C(=O)N)NC(=O)CNC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]cn3)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(=O)O)N
Properties
C55H79N13O14S2
Molar mass 1210.43
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Neurokinin B (NKB) belongs in the family of tachykinin peptides. Neurokinin B is implicated in a variety of human functions and pathways such as the secretion of gonadotropin-releasing hormone.[1] Additionally, NKB is associated with pregnancy in females and maturation in young adults. Reproductive function is highly dependent on levels of both neurokinin B and also the G-protein coupled receptor ligand kisspeptin.[2] The first NKB studies done attempted to resolve why high levels of the peptide may be implicated in pre-eclampsia during pregnancy.[3] NKB, kisspeptin, and dynorphin together are found in the arcuate nucleus (ARC) known as the KNDy subpopulation. This subpopulation is targeted by many steroid hormones and works to form a network that feeds back to GnRH pulse generator.[4]

  1. ^ Goodman, R.L; Coolen, L.M; Lehman, M.N (July 2014). "A Role for Neurokinin B in Pulsatile GnRH Secretion in the Ewe". Neuroendocrinology. 99 (1): 18–32. doi:10.1159/000355285. PMC 3976461. PMID 24008670.
  2. ^ Navarro, VM (2013). "Interactions Between Kisspeptins and Neurokinin B". Kisspeptin Signaling in Reproductive Biology. Advances in Experimental Medicine and Biology. Vol. 784. pp. 325–347. doi:10.1007/978-1-4614-6199-9_15. ISBN 978-1-4614-6198-2. PMC 3858905. PMID 23550013.
  3. ^ Rie, Sakamoto; hisao, Osada; Yoshinori, Litsuka; Kentarou, Masuda; Kenshi, Kaku; Katsuyoshi, Seki; Souei, Sekiya (17 Apr 2003). "Profile of neurokinin B concentrations in maternal and cord blood in normal pregnancy". Clinical Endocrinology. 58 (5): 597–600. doi:10.1046/j.1365-2265.2003.01758.x. PMID 12699441. S2CID 30312551.
  4. ^ Lehman, Michael; Coolen, Lique; Goodman, Robert (August 2010). "Minireview: Kisspeptin/Neurokinin B/ Dynorphin Cells of the Arcuate Nucleus: A central Node in the Control of Gonadotorpin-Releasing Hormone Secretion". Endocrinology. 151 (8): 3479–3489. doi:10.1210/en.2010-0022. PMC 2940527. PMID 20501670.