Neuropeptide Y receptor Y2

NPY2R
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2IK3
Identifiers
Aliases	NPY2R, NPY2-R, Neuropeptide Y receptor Y2
External IDs	OMIM: 162642; MGI: 108418; HomoloGene: 701; GeneCards: NPY2R; OMA:NPY2R - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	155,217,078 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	82,455,391 bp
RNA expression pattern
	Top expressed in
	testicle; ; optic nerve; ; pancreatic ductal cell; ; lactiferous duct; ; prefrontal cortex; ; hypothalamus; ; tibialis anterior muscle; ; nucleus accumbens; ; right coronary artery; ; Brodmann area 9;
	Top expressed in
	median eminence; ; lumbar spinal ganglion; ; arcuate nucleus; ; dentate gyrus of hippocampal formation granule cell; ; hippocampus proper; ; anterior amygdaloid area; ; subiculum; ; CA3 field; ; globus pallidus; ; area postrema;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	neuropeptide Y receptor activity; G protein-coupled receptor activity; calcium channel regulator activity; signal transducer activity; protein binding; peptide YY receptor activity; signaling receptor activity;
Cellular component	integral component of membrane; membrane; plasma membrane; integral component of plasma membrane; intracellular anatomical structure; non-motile cilium; cilium;
Biological process	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; regulation of sensory perception of pain; locomotory behavior; positive regulation of cytosolic calcium ion concentration; positive regulation of peptide secretion; outflow tract morphogenesis; cardiac left ventricle morphogenesis; negative regulation of nervous system process; negative regulation of synaptic transmission; behavioral fear response; negative regulation of excitatory postsynaptic potential; secretion; positive regulation of circadian sleep/wake cycle, non-REM sleep; positive regulation of dopamine secretion; negative regulation of secretion; feeding behavior; negative regulation of feeding behavior; nitric oxide mediated signal transduction; neuropeptide signaling pathway; positive regulation of smooth muscle contraction; negative regulation of synaptic transmission, glutamatergic; signal transduction; positive regulation of cell-substrate adhesion; human ageing; chemical synaptic transmission; G protein-coupled receptor signaling pathway; negative regulation of cAMP-mediated signaling;
	Sources:Amigo / QuickGO
Orthologs
	4887
	18167
	ENSG00000185149
	ENSMUSG00000028004
	P49146
	P97295
	NM_000910; NM_001370180; NM_001375470
	NM_001205099; NM_008731
	NP_000901; NP_001357109; NP_001362399
	NP_001192028; NP_032757
	Wikidata
View/Edit Human	View/Edit Mouse

Neuropeptide Y receptor type 2 (Y2R) is a member of the neuropeptide Y receptor family of G-protein coupled receptors, that in humans is encoded by the NPY2R gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000185149 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028004 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Rose PM, Fernandes P, Lynch JS, Frazier ST, Fisher SM, Kodukula K, Kienzle B, Seethala R (Sep 1995). "Cloning and functional expression of a cDNA encoding a human type 2 neuropeptide Y receptor". The Journal of Biological Chemistry. 270 (39): 22661–4. doi:10.1074/jbc.270.39.22661. PMID 7559383.
^ "Entrez Gene: NPY2R neuropeptide Y receptor Y2".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000185149 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028004 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7559383-5] Rose PM, Fernandes P, Lynch JS, Frazier ST, Fisher SM, Kodukula K, Kienzle B, Seethala R (Sep 1995). "Cloning and functional expression of a cDNA encoding a human type 2 neuropeptide Y receptor". The Journal of Biological Chemistry. 270 (39): 22661–4. doi:10.1074/jbc.270.39.22661. PMID 7559383.

[entrez-6] "Entrez Gene: NPY2R neuropeptide Y receptor Y2".

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