Neurophysin II

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arginine vasopressin (neurophysin II, antidiuretic hormone, diabetes insipidus, neurohypophyseal)
neurophysin II, Bos taurus
Identifiers
Symbol	AVP
Alt. symbols	ARVP
NCBI gene	551
HGNC	894
OMIM	192340
RefSeq	NM_000490
UniProt	P01185
Other data
Locus	Chr. 20 p13
Search for Structures Swiss-model Domains InterPro

Neurophysin II is a carrier protein with a size of 19,687.3 Da and is made up of a dimer of two virtually identical chains of amino acids. Neurophysin II is a cleavage product (formed by splitting of a compound molecule into a simpler one) of the AVP gene. It is a neurohypophysial hormone that is transported in vesicles with vasopressin, the other cleavage product, along axons, from magnocellular neurons of the hypothalamus to the posterior lobe of the pituitary. Although it is stored in neurosecretory granules with vasopressin and released with vasopressin into the bloodstream, its biological action is unclear. Neurophysin II is also known as a stimulator of prolactin secretion.